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3ia5

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==Moritella profunda dihydrofolate reductase (DHFR)==
==Moritella profunda dihydrofolate reductase (DHFR)==
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<StructureSection load='3ia5' size='340' side='right' caption='[[3ia5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3ia5' size='340' side='right'caption='[[3ia5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ia5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bccm/lmg:21259 Bccm/lmg:21259]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IA5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bccm/lmg:21259 Bccm/lmg:21259]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ia4|3ia4]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ia4|3ia4]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 BCCM/LMG:21259])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dyrA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 BCCM/LMG:21259])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia5 OCA], [http://pdbe.org/3ia5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ia5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ia5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia5 OCA], [https://pdbe.org/3ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
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[[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Bccm/lmg:21259]]
[[Category: Bccm/lmg:21259]]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
[[Category: Allemann, R K]]
[[Category: Allemann, R K]]
[[Category: Evans, R M]]
[[Category: Evans, R M]]

Revision as of 11:01, 13 April 2022

Moritella profunda dihydrofolate reductase (DHFR)

PDB ID 3ia5

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