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Terminase

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The large subunit of Ter is composed of an <scene name='77/775254/Cv/5'>N-terminal ATPase domain, a linker region and a C-terminal nuclease domain</scene>. ATP binds to the protein in a <scene name='77/775254/Cv/6'>groove between the ATPase domain and the linker region</scene><ref>PMID:23630261</ref>.
The large subunit of Ter is composed of an <scene name='77/775254/Cv/5'>N-terminal ATPase domain, a linker region and a C-terminal nuclease domain</scene>. ATP binds to the protein in a <scene name='77/775254/Cv/6'>groove between the ATPase domain and the linker region</scene><ref>PMID:23630261</ref>.
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</StructureSection>
 
== 3D Structures of terminase ==
== 3D Structures of terminase ==
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[[Terminase 3D Structures ]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Terminase small subunit
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**[[3n4p]], [[3n4q]] – HvTer nuclease domain – Herpesvirus<br />
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**[[6ey7]] – HvTer nuclease domain + inhibitor<br />
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**[[3hef]] – Ter – Bacteriophage T7 <br />
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**[[4zc3]], [[2cmp]] – Sf6Ter nuclease domain – Bacteriophage Sf6 <br />
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**[[4dyc]], [[4dzj]], [[4dzp]] – Sf6Ter nuclease domain (mutant) <br />
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**[[3zqp]], [[3zqm]], [[3zqn]], [[3zqo]] – Sf6Ter oligomerization domain <br />
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**[[3zqq]], [[4dyq]], [[4dyr]] – Sf6Ter <br />
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**[[1j9i]] – Ter nuclease domain – Bacteriophage λ - NMR <br />
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**[[4xvn]] – G20cTer nuclease domain – Bacteriophage G20c <br />
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**[[3p9a]] – Ter – Bacteriophage P22 <br />
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**[[6v1i]] – Ter – Thermus virus – Cryo EM<br />
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**[[6ejq]] – Ter – Thermus phage<br />
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**[[6hn7]] – Ter + RPPC – ''E. coli'' virus λ <br />
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**[[7joq]] – Ter – Pseudomonas phage NV1<br />
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**[[6w7t]] – Ter – Pseudomonas phage PaP3<br />
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*Terminase large subunit
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**[[4dkw]] – Ter nuclease domain – Bacteriophage P22<br />
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**[[4bij]], [[4bil]] – T7Ter – Bacteriophage T7 – Cryo EM<br />
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**[[4idh]] – T7Ter <br />
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**[[2wbn]], [[2wc9]] – Ter nuclease domain – Bacteriophage Spp1 <br />
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**[[3c6a]], [[3c6h]] – Ter nuclease domain – Bacteriophage Rb49 <br />
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**[[5c10]], [[5c12]] – Sf6Ter nuclease domain <br />
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**[[5c2d]], [[5c15]] – Sf6Ter nuclease domain (mutant)<br />
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**[[5m1f]], [[5m1k]], [[5m1n]], [[5m1o]], [[5m1p]], [[5m1q]] – G20cTer <br />
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**[[5oe8]], [[5oee]], [[5oe9]] – D6eTer – Bacteriophage D6e <br />
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**[[5tge]] – P74Ter nuclease domain – Thermus phage P74 <br />
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**[[4zni]], [[4znk]] – P74Ter ATPase domain <br />
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**[[4znj]] – P74Ter ATPase domain (mutant)<br />
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**[[4znl]] – P74Ter ATPase domain + ADP <br />
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*Terminase large subunit complex
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**[[4iee]], [[4ife]] – Sf6Ter + ATP<br />
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**[[4iei]] – Sf6Ter + ADP<br />
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**[[5c2f]] – Sf6Ter nuclease domain (mutant) + antifungal drug<br />
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**[[5oea]] – D6eTer + ATP <br />
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**[[5oeb]] – D6eTer + ADP <br />
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**[[6vi1]], [[6xmi]] – Ter + antibody – Salmonella phage P22<br />
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*Tripartite terminase
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**[[6m5s]], [[6m5r]] – HvTer TRM1+TRM2+TRM3 – Cryo EM<br />
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**[[6m5u]], [[6m5v]] – HvTer TRM1+TRM2+TRM3 + ADP – Cryo EM<br />
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**[[6m5t]] – HvTer TRM3 – Cryo EM<br />
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}}
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Terminase large subunit complex with ATP (PDB code 4ife)

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References

  1. ↑ PMID:22297528
  2. ↑ Sankhala RS, Lokareddy RK, Cingolani G. Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J Biol Chem. 2016 Mar 31. pii: jbc.M116.724393. PMID:27033706 doi:http://dx.doi.org/10.1074/jbc.M116.724393
  3. ↑ Heming JD, Huffman JB, Jones LM, Homa FL. Isolation and characterization of the herpes simplex virus 1 terminase complex. J Virol. 2014 Jan;88(1):225-36. doi: 10.1128/JVI.02632-13. Epub 2013 Oct 23. PMID:24155374 doi:http://dx.doi.org/10.1128/JVI.02632-13
  4. ↑ Zhao H, Christensen TE, Kamau YN, Tang L. Structures of the phage Sf6 large terminase provide new insights into DNA translocation and cleavage. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8075-8080. Epub 2013 Apr 29. PMID:23630261 doi:10.1073/pnas.1301133110

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