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3iti

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[[Image:3iti.png|left|200px]]
 
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==Structure of bovine trypsin with the MAD triangle B3C==
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The line below this paragraph, containing "STRUCTURE_3iti", creates the "Structure Box" on the page.
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<StructureSection load='3iti' size='340' side='right'caption='[[3iti]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iti]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ITI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BRV:5-AMINO-2,4,6-TRIBROMOBENZENE-1,3-DICARBOXYLIC+ACID'>BRV</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3e3d|3e3d]], [[3e3s|3e3s]], [[3e3t|3e3t]], [[3gt3|3gt3]], [[3gt4|3gt4]]</div></td></tr>
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{{STRUCTURE_3iti| PDB=3iti | SCENE= }}
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iti OCA], [https://pdbe.org/3iti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iti RCSB], [https://www.ebi.ac.uk/pdbsum/3iti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iti ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/3iti_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iti ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The magic triangle 5-amino-2,4,6-triiodoisophthalic acid (I3C) and the MAD triangle 5-amino-2,4,6-tribromoisophthalic acid (B3C) are two representatives of a novel class of compounds that combine heavy atoms for experimental phasing with functional groups for protein interactions. These compounds are readily available and provide easy access to experimental phasing. The preparation of stock solutions and the incorporation of the compounds into protein crystals are discussed. As an example of incorporation via cocrystallization, the incorporation of B3C into bovine trypsin, resulting in a single site with high occupancy, is described.
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===Structure of bovine trypsin with the MAD triangle B3C===
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How to get the magic triangle and the MAD triangle into your protein crystal.,Beck T, da Cunha CE, Sheldrick GM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):1068-70., Epub 2009 Sep 25. PMID:19851024<ref>PMID:19851024</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19851024}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3iti" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19851024 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_19851024}}
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==About this Structure==
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[[3iti]] is a 1 chain structure of [[Trypsin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITI OCA].
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==See Also==
==See Also==
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*[[Trypsin]]
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019851024</ref><ref group="xtra">PMID:019407425</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Trypsin]]
[[Category: Trypsin]]
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[[Category: Beck, T.]]
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[[Category: Beck, T]]
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[[Category: Cunha, C E.da.]]
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[[Category: Cunha, C E.da]]
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[[Category: Sheldrick, G M.]]
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[[Category: Sheldrick, G M]]
[[Category: 5-amino-2]]
[[Category: 5-amino-2]]
[[Category: 6-tribromoisophthalic acid]]
[[Category: 6-tribromoisophthalic acid]]

Current revision

Structure of bovine trypsin with the MAD triangle B3C

PDB ID 3iti

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OCA

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