Topoisomerase binding protein

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<StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry [[3ueo]])' scene=''>
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<StructureSection load='' size='350' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (magenta) (PDB entry [[3ueo]])' scene='56/564070/Cv/4'>
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== Function ==
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'''Topoisomerase binding protein''' or '''DNA topoisomerase 2-binding protein 1''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>.
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'''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides.
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== Structural highlights ==
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TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides. The <scene name='56/564070/Cv/5'>phospho-peptide interacts with BRCT4 and BRCT5 of both monomers</scene><ref>PMID:23891287</ref>.
==3D structures of topoisomerase binding protein==
==3D structures of topoisomerase binding protein==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[3jve]], [[3pd7]] – hTopBP1 BRCT 6 domain – human<br />
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Domains - BRCT 0-2 1-287; BRCT 4-5 549-746; BRCT 6 893-996; BRCT 7-8 1264-1493
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[[2xnh]], [[2xnk]] – hTopBP1 BRCT 0-2 domains <br />
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[[2xnh]], [[2xnk]] – hTopBP1 BRCT 0-2 domains - human <br />
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[[6hm5]] – hTopBP1 BRCT 0-2 domains + Rad9<br />
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[[6rml]] – hTopBP1 BRCT 0-2 domains + 53bp1<br />
[[3olc]] – hTopBP1 N terminal <br />
[[3olc]] – hTopBP1 N terminal <br />
[[3uen]] – hTopBP1 BRCT 4-5 domains <br />
[[3uen]] – hTopBP1 BRCT 4-5 domains <br />
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[[3ueo]] – hTopBP1 BRCT 4-5 domains + phosphor-peptide<br />
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[[3ueo]], [[5u6k]], [[6rmm]] – hTopBP1 BRCT 4-5 domains + phosphor-peptide<br />
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[[5u6k]] – hTopBP1 BRCT 4-5 domains + BLM<br />
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[[3jve]], [[3pd7]] – hTopBP1 BRCT 6 domain <br />
[[3al2]] – hTopBP1 BRCT 7-8 domains <br />
[[3al2]] – hTopBP1 BRCT 7-8 domains <br />
[[3al3]] – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide<br />
[[3al3]] – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide<br />
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[[7cmz]] – hTopBP1 BRCT 7-8 domains + PHF8 peptide<br />
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== References ==
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<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (magenta) (PDB entry 3ueo)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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