Topoisomerase binding protein
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (magenta) (PDB entry [[3ueo]])' scene='56/564070/Cv/4'> | <StructureSection load='' size='350' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (magenta) (PDB entry [[3ueo]])' scene='56/564070/Cv/4'> | ||
== Function == | == Function == | ||
| - | '''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. | + | '''Topoisomerase binding protein''' or '''DNA topoisomerase 2-binding protein 1''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. |
== Structural highlights == | == Structural highlights == | ||
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[[2xnh]], [[2xnk]] – hTopBP1 BRCT 0-2 domains - human <br /> | [[2xnh]], [[2xnk]] – hTopBP1 BRCT 0-2 domains - human <br /> | ||
| + | [[6hm5]] – hTopBP1 BRCT 0-2 domains + Rad9<br /> | ||
| + | [[6rml]] – hTopBP1 BRCT 0-2 domains + 53bp1<br /> | ||
[[3olc]] – hTopBP1 N terminal <br /> | [[3olc]] – hTopBP1 N terminal <br /> | ||
[[3uen]] – hTopBP1 BRCT 4-5 domains <br /> | [[3uen]] – hTopBP1 BRCT 4-5 domains <br /> | ||
| - | [[3ueo]] – hTopBP1 BRCT 4-5 domains + phosphor-peptide<br /> | + | [[3ueo]], [[5u6k]], [[6rmm]] – hTopBP1 BRCT 4-5 domains + phosphor-peptide<br /> |
[[5u6k]] – hTopBP1 BRCT 4-5 domains + BLM<br /> | [[5u6k]] – hTopBP1 BRCT 4-5 domains + BLM<br /> | ||
[[3jve]], [[3pd7]] – hTopBP1 BRCT 6 domain <br /> | [[3jve]], [[3pd7]] – hTopBP1 BRCT 6 domain <br /> | ||
[[3al2]] – hTopBP1 BRCT 7-8 domains <br /> | [[3al2]] – hTopBP1 BRCT 7-8 domains <br /> | ||
[[3al3]] – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide<br /> | [[3al3]] – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide<br /> | ||
| + | [[7cmz]] – hTopBP1 BRCT 7-8 domains + PHF8 peptide<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
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