2y6c
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6C FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mmp|1mmp]], [[1mmr|1mmr]], [[1mmq|1mmq]], [[2y6d|2y6d]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mmp|1mmp]], [[1mmr|1mmr]], [[1mmq|1mmq]], [[2y6d|2y6d]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Matrilysin Matrilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.23 3.4.24.23] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [https://pdbe.org/2y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [https://www.ebi.ac.uk/pdbsum/2y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6c ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN]] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref> |
==See Also== | ==See Also== | ||
Revision as of 12:23, 27 April 2022
The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger
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Categories: Human | Large Structures | Matrilysin | Edman, K | Furber, M | Hemsley, P | Johansson, C | Pairaudeau, G | Petersen, J | Stocks, M | Tervo, A | Ward, A | Wells, E | Wissler, L | Hydrolase
