NKX2.5 Homeodomain

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
You may include any references to papers as in the use of JSmol in Proteopedia <ref>Pradhan, L., Genis, C., Scone, P., Weinberg, E. O., Kasahara, H., & Nam, H. J. (2012). Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51(32), 6312–6319. https://doi.org/10.1021/bi300849c</ref> or to the article describing Jmol <ref>10.1021/bi300849c</ref> to the rescue.
You may include any references to papers as in the use of JSmol in Proteopedia <ref>Pradhan, L., Genis, C., Scone, P., Weinberg, E. O., Kasahara, H., & Nam, H. J. (2012). Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51(32), 6312–6319. https://doi.org/10.1021/bi300849c</ref> or to the article describing Jmol <ref>10.1021/bi300849c</ref> to the rescue.
-
== Structural Description ==
+
= General Information =
-
NKX2.5 belongs to the NK2-family of homeodomain transcription factors. These
+
 
-
homeodomain proteins function to regulate the transcription of genes important for development.
+
The homeodomain NKX2.5 is one of multiple transcription factors that work in conjunction during cardiogenesis <ref> Olson, E. N. (2006) Gene regulatory networks in the evolution and development of the heart. Science 313, 1922−1927. </ref>. In addition to the function NKX2.5 plays in cardiac development, the transcription factor also plays a role
-
Proteins in the NK2-family regulate the development of structures through DNA binding at an
+
 
-
endogenous site. These proteins are classified by the conservation of Try54, which is essential
+
=== Clinical Relevance ===
-
for promoter site recognition. The NK2-family also includes a C-terminal regulatory domain.
+
 
-
NKX2.5 is of particular interest as it has been shown to mediate carcinogenesis.
+
 
== Protein / DNA Interactions ==
== Protein / DNA Interactions ==
Scene <scene name='91/911264/Test/1'>wicked cool scene</scene>
Scene <scene name='91/911264/Test/1'>wicked cool scene</scene>
-
== Mutational Analysis ==
+
=== Mutational Analysis ===
-
 
+
-
== Protein / DNA interactions ==
+
-
== Clinical Relevance ==
+
= Protein / DNA interactions =
== Structural highlights ==
== Structural highlights ==

Revision as of 02:32, 2 May 2022

NKX2.5 Homeodomain

PDB ID 3RKQ

Drag the structure with the mouse to rotate

References

  1. ↑ Pradhan, L., Genis, C., Scone, P., Weinberg, E. O., Kasahara, H., & Nam, H. J. (2012). Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51(32), 6312–6319. https://doi.org/10.1021/bi300849c
  2. ↑ 10.1021/bi300849c
  3. ↑ Olson, E. N. (2006) Gene regulatory networks in the evolution and development of the heart. Science 313, 1922−1927.

Proteopedia Page Contributors and Editors (what is this?)

William J Simard, Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/NKX2.5_Homeodomain"
Personal tools