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Autocrine signaling
From Proteopedia
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'''Interleukin 6''' | '''Interleukin 6''' | ||
*[[Interleukins]] | *[[Interleukins]] | ||
| - | Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated [[Stepler sandbox STAT3|STAT3]] (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. | + | Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated [[Stepler sandbox STAT3|STAT3]] (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. Further investigation revealed that mutant [[EGFR]] could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. |
Revision as of 12:52, 4 May 2022
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