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7o21
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7o21 is ON HOLD Authors: Lovering, A.L., Valdivia-Delgado, M. Description: Structure of Bdellovibrio bacteriovorus Bd1075 [[Category: Unreleased St...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Bdellovibrio bacteriovorus Bd1075== | |
| + | <StructureSection load='7o21' size='340' side='right'caption='[[7o21]], [[Resolution|resolution]] 1.34Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7o21]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdeba Bdeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O21 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bd1075 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264462 BDEBA])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o21 OCA], [https://pdbe.org/7o21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o21 RCSB], [https://www.ebi.ac.uk/pdbsum/7o21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o21 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peptidoglycan hydrolases contribute to the generation of helical cell shape in Campylobacter and Helicobacter bacteria, while cytoskeletal or periskeletal proteins determine the curved, vibrioid cell shape of Caulobacter and Vibrio. Here, we identify a peptidoglycan hydrolase in the vibrioid-shaped predatory bacterium Bdellovibrio bacteriovorus which invades and replicates within the periplasm of Gram-negative prey bacteria. The protein, Bd1075, generates cell curvature in B. bacteriovorus by exerting LD-carboxypeptidase activity upon the predator cell wall as it grows inside spherical prey. Bd1075 localizes to the outer convex face of B. bacteriovorus; this asymmetric localization requires a nuclear transport factor 2-like (NTF2) domain at the protein C-terminus. We solve the crystal structure of Bd1075, which is monomeric with key differences to other LD-carboxypeptidases. Rod-shaped Deltabd1075 mutants invade prey more slowly than curved wild-type predators and stretch invaded prey from within. We therefore propose that the vibrioid shape of B. bacteriovorus contributes to predatory fitness. | ||
| - | + | Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria.,Banks EJ, Valdivia-Delgado M, Biboy J, Wilson A, Cadby IT, Vollmer W, Lambert C, Lovering AL, Sockett RE Nat Commun. 2022 Mar 21;13(1):1509. doi: 10.1038/s41467-022-29007-y. PMID:35314810<ref>PMID:35314810</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Lovering, A | + | <div class="pdbe-citations 7o21" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bdeba]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lovering, A L]] | ||
[[Category: Valdivia-Delgado, M]] | [[Category: Valdivia-Delgado, M]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Peptidoglycan ld-carboxypeptidase ntf2]] | ||
Current revision
Structure of Bdellovibrio bacteriovorus Bd1075
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