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1h2q

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[[Image:1h2q.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h2q OCA], [http://www.ebi.ac.uk/pdbsum/1h2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h2q RCSB]</span>
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'''HUMAN CD55 DOMAINS 3 & 4'''
'''HUMAN CD55 DOMAINS 3 & 4'''
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[[Category: Spiller, O B.]]
[[Category: Spiller, O B.]]
[[Category: Williams, P.]]
[[Category: Williams, P.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: bacterial receptor]]
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[[Category: Bacterial receptor]]
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[[Category: complement decay accelerating factor]]
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[[Category: Complement decay accelerating factor]]
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[[Category: complement pathway]]
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[[Category: Complement pathway]]
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[[Category: enteroviral receptor]]
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[[Category: Enteroviral receptor]]
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[[Category: gpi-anchor]]
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[[Category: Gpi-anchor]]
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[[Category: ligand for cd97]]
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[[Category: Ligand for cd97]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:21:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:56:34 2008''
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Revision as of 15:21, 2 May 2008

Image:1h2q.gif

Template:STRUCTURE 1h2q

HUMAN CD55 DOMAINS 3 & 4


Overview

Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.

About this Structure

1H2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389 Page seeded by OCA on Fri May 2 18:21:13 2008

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