1h3m

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[[Image:1h3m.jpg|left|200px]]
[[Image:1h3m.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1h3m |SIZE=350|CAPTION= <scene name='initialview01'>1h3m</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1h3m", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:N2p+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N2P:PENTANE-1,5-DIAMINE'>N2P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h3m| PDB=1h3m | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3m OCA], [http://www.ebi.ac.uk/pdbsum/1h3m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h3m RCSB]</span>
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}}
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'''STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE'''
'''STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE'''
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[[Category: Hunter, W N.]]
[[Category: Hunter, W N.]]
[[Category: Kemp, L E.]]
[[Category: Kemp, L E.]]
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[[Category: isoprenoid]]
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[[Category: Isoprenoid]]
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[[Category: synthetase]]
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[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:23:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:56:59 2008''
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Revision as of 15:23, 2 May 2008

Image:1h3m.jpg

Template:STRUCTURE 1h3m

STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE


Overview

2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase is an essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis. The structure of a tetragonal crystal form has been solved by molecular replacement and refined to 2.4 A resolution. Structure and sequence comparisons suggest that the enzyme is a suitable target for a structure-based approach to the development of novel broad-spectrum antibiotics. However, the absence of ligands in the enzyme active site together with the moderate resolution of the structure indicates that this tetragonal crystal form is inferior to that of a previously reported highly ordered monoclinic form [Richard et al. (2001), Nature Struct. Biol. 8, 641-647].

About this Structure

1H3M is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase., Kemp LE, Bond CS, Hunter WN, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):607-10. Epub 2003, Feb 21. PMID:12595740 Page seeded by OCA on Fri May 2 18:23:28 2008

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