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3mxm
From Proteopedia
(Difference between revisions)
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==TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant== | ==TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant== | ||
| - | <StructureSection load='3mxm' size='340' side='right' caption='[[3mxm]], [[Resolution|resolution]] 1.75Å' scene=''> | + | <StructureSection load='3mxm' size='340' side='right'caption='[[3mxm]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3mxm]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3mxm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXM FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oa8|2oa8]], [[2ioc|2ioc]], [[3mxi|3mxi]], [[3mxj|3mxj]], [[3mxk|3mxk]], [[3n0o|3n0o]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2oa8|2oa8]], [[2ioc|2ioc]], [[3mxi|3mxi]], [[3mxj|3mxj]], [[3mxk|3mxk]], [[3n0o|3n0o]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trex1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trex1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exodeoxyribonuclease_III Exodeoxyribonuclease III], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.2 3.1.11.2] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxm OCA], [https://pdbe.org/3mxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxm RCSB], [https://www.ebi.ac.uk/pdbsum/3mxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxm ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TREX1_MOUSE TREX1_MOUSE]] Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair.<ref>PMID:10391904</ref> <ref>PMID:11279105</ref> |
==See Also== | ==See Also== | ||
| - | *[[Exonuclease|Exonuclease]] | + | *[[Exonuclease 3D structures|Exonuclease 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Exodeoxyribonuclease III]] | [[Category: Exodeoxyribonuclease III]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Bailey, S L]] | [[Category: Bailey, S L]] | ||
Revision as of 06:52, 12 May 2022
TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant
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