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3nwe

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==Rat COMT in complex with a methylated desoxyribose bisubstrate-containing inhibitor avoids hydroxyl group==
==Rat COMT in complex with a methylated desoxyribose bisubstrate-containing inhibitor avoids hydroxyl group==
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<StructureSection load='3nwe' size='340' side='right' caption='[[3nwe]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='3nwe' size='340' side='right'caption='[[3nwe]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nwe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NWE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=662:5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-N-[(E)-3-[(2R,3R,4R,5R)-4-HYDROXY-3-METHYL-5-[6-(PROPYLAMINO)PURIN-9-YL]OXOLAN-2-YL]PROP-2-ENYL]BENZAMIDE'>662</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=662:5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-N-[(E)-3-[(2R,3R,4R,5R)-4-HYDROXY-3-METHYL-5-[6-(PROPYLAMINO)PURIN-9-YL]OXOLAN-2-YL]PROP-2-ENYL]BENZAMIDE'>662</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nw9|3nw9]], [[3nwb|3nwb]], [[3ozr|3ozr]], [[3ozs|3ozs]], [[3ozt|3ozt]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nw9|3nw9]], [[3nwb|3nwb]], [[3ozr|3ozr]], [[3ozs|3ozs]], [[3ozt|3ozt]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Comt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Comt ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwe OCA], [http://pdbe.org/3nwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nwe RCSB], [http://www.ebi.ac.uk/pdbsum/3nwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwe ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwe OCA], [https://pdbe.org/3nwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwe RCSB], [https://www.ebi.ac.uk/pdbsum/3nwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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[[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3nwe" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3nwe" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Buffalo rat]]
[[Category: Buffalo rat]]
[[Category: Catechol O-methyltransferase]]
[[Category: Catechol O-methyltransferase]]
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[[Category: Large Structures]]
[[Category: Benz, J]]
[[Category: Benz, J]]
[[Category: Ehler, A]]
[[Category: Ehler, A]]

Revision as of 07:10, 12 May 2022

Rat COMT in complex with a methylated desoxyribose bisubstrate-containing inhibitor avoids hydroxyl group

PDB ID 3nwe

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