This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3nws
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13== | ==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13== | ||
| - | <StructureSection load='3nws' size='340' side='right' caption='[[3nws]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3nws' size='340' side='right'caption='[[3nws]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3nws]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3nws]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWS FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nwt|3nwt]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nwt|3nwt]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nws OCA], [https://pdbe.org/3nws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nws RCSB], [https://www.ebi.ac.uk/pdbsum/3nws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nws ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Atcc 18824]] | [[Category: Atcc 18824]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Harper, S]] | [[Category: Harper, S]] | ||
[[Category: Johnson, F B]] | [[Category: Johnson, F B]] | ||
Revision as of 07:11, 12 May 2022
Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13
| |||||||||||
