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1h6j

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[[Image:1h6j.gif|left|200px]]
[[Image:1h6j.gif|left|200px]]
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{{Structure
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|PDB= 1h6j |SIZE=350|CAPTION= <scene name='initialview01'>1h6j</scene>, resolution 2.32&Aring;
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The line below this paragraph, containing "STRUCTURE_1h6j", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-manno-octulosonate_cytidylyltransferase 3-deoxy-manno-octulosonate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.38 2.7.7.38] </span>
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{{STRUCTURE_1h6j| PDB=1h6j | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6j OCA], [http://www.ebi.ac.uk/pdbsum/1h6j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h6j RCSB]</span>
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'''THE THREE-DIMENSIONAL STRUCTURE OF CAPSULE-SPECIFIC CMP:2-KETO-3-DEOXY-MANNO-OCTONIC ACID SYNTHETASE FROM ESCHERICHIA COLI'''
'''THE THREE-DIMENSIONAL STRUCTURE OF CAPSULE-SPECIFIC CMP:2-KETO-3-DEOXY-MANNO-OCTONIC ACID SYNTHETASE FROM ESCHERICHIA COLI'''
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[[Category: Jelakovic, S.]]
[[Category: Jelakovic, S.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: capsular polysaccharide]]
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[[Category: Capsular polysaccharide]]
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[[Category: cmp-kdo synthetase]]
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[[Category: Cmp-kdo synthetase]]
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[[Category: saccharide activation]]
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[[Category: Saccharide activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:58:47 2008''
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Revision as of 15:29, 2 May 2008

Image:1h6j.gif

Template:STRUCTURE 1h6j

THE THREE-DIMENSIONAL STRUCTURE OF CAPSULE-SPECIFIC CMP:2-KETO-3-DEOXY-MANNO-OCTONIC ACID SYNTHETASE FROM ESCHERICHIA COLI


Overview

CMP-Kdo synthetases from Gram-negative bacteria activate Kdo for incorporation into lipo- and capsule-polysaccharides. Here we report the crystal structure of the capsule-specific synthetase from E. coli at 2.3 A resolution. The enzyme is a dimer of 2 x 245 amino acid residues assuming C2 symmetry. It contains a central predominantly parallel beta-sheet with surrounding helices. The chain fold is novel; it is remotely related to a double Rossmann fold. A large pocket at the carboxyl terminal ends of the central. beta-strands most likely accommodates the catalytic center. A putative phosphate binding site at the loop between the first beta-strand and the following helix is indicated by a bound iridium hexachloride anion.

About this Structure

1H6J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of capsule-specific CMP: 2-keto-3-deoxy-manno-octonic acid synthetase from Escherichia coli., Jelakovic S, Jann K, Schulz GE, FEBS Lett. 1996 Aug 5;391(1-2):157-61. PMID:8706906 Page seeded by OCA on Fri May 2 18:29:46 2008

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