7zeg
From Proteopedia
(Difference between revisions)
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==Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP== | ==Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP== | ||
| - | <StructureSection load='7zeg' size='340' side='right'caption='[[7zeg]]' scene=''> | + | <StructureSection load='7zeg' size='340' side='right'caption='[[7zeg]], [[Resolution|resolution]] 1.56Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7zeg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zeg OCA], [https://pdbe.org/7zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zeg RCSB], [https://www.ebi.ac.uk/pdbsum/7zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zeg ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOO:N7-(3,4-difluorobenzyl)+guanosine+5-monophosphate'>IOO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zeg OCA], [https://pdbe.org/7zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zeg RCSB], [https://www.ebi.ac.uk/pdbsum/7zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zeg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/5NT3B_HUMAN 5NT3B_HUMAN]] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).<ref>PMID:23223233</ref> <ref>PMID:24603684</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baranowski | + | [[Category: Baranowski, M R]] |
| - | [[Category: Basquin J]] | + | [[Category: Basquin, J]] |
| - | [[Category: Jemielity J]] | + | [[Category: Jemielity, J]] |
| - | [[Category: Kowalska J]] | + | [[Category: Kowalska, J]] |
| - | [[Category: Kozarski M]] | + | [[Category: Kozarski, M]] |
| - | [[Category: Kubacka D]] | + | [[Category: Kubacka, D]] |
| - | [[Category: Wojcik R]] | + | [[Category: Wojcik, R]] |
| + | [[Category: Cytosolic 5' nucleotidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mrna cap degradation]] | ||
| + | [[Category: N7 methylguanosine monophosphate dephosphorylation]] | ||
Revision as of 08:19, 25 May 2022
Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP
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