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3q1p

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[[Image:3q1p.jpg|left|200px]]
 
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==Crystal structure of CDP-Chase==
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The line below this paragraph, containing "STRUCTURE_3q1p", creates the "Structure Box" on the page.
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<StructureSection load='3q1p' size='340' side='right'caption='[[3q1p]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q1p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baccr Baccr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3q1p| PDB=3q1p | SCENE= }}
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q4i|3q4i]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC2032, BC_2032 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1p OCA], [https://pdbe.org/3q1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1p RCSB], [https://www.ebi.ac.uk/pdbsum/3q1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1p ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A Nudix enzyme from Bacillus cereus (NCBI RefSeq accession no. NP_831800) catalyzes the hydrolysis of CDP-choline to produce CMP and phosphocholine. Here, we show that in addition, the enzyme has a 3'--&gt;5' RNA exonuclease activity. The structure of the free enzyme, determined to a 1.8-A resolution, shows that the enzyme is an asymmetric dimer. Each monomer consists of two domains, an N-terminal helical domain and a C-terminal Nudix domain. The N-terminal domain is placed relative to the C-terminal domain such as to result in an overall asymmetric arrangement with two distinct catalytic sites: one with an "enclosed" Nudix pyrophosphatase site and the other with a more open, less-defined cavity. Residues that may be important for determining the asymmetry are conserved among a group of uncharacterized Nudix enzymes from Gram-positive bacteria. Our data support a model where CDP-choline hydrolysis is catalyzed by the enclosed Nudix site and RNA exonuclease activity is catalyzed by the open site. CDP-Chase is the first identified member of a novel Nudix family in which structural asymmetry has a profound effect on the recognition of substrates.
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===Crystal structure of CDP-Chase===
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The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities.,Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM J Bacteriol. 2011 Jul;193(13):3175-85. Epub 2011 Apr 29. PMID:21531795<ref>PMID:21531795</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21531795}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3q1p" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21531795 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21531795}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Baccr]]
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[[3q1p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1P OCA].
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[[Category: Large Structures]]
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[[Category: Amzel, L M]]
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==Reference==
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[[Category: Duong-Ly, K C]]
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<ref group="xtra">PMID:021531795</ref><references group="xtra"/>
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[[Category: Gabelli, S B]]
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[[Category: Bacillus cereus]]
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[[Category: Amzel, L M.]]
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[[Category: Duong-Ly, K C.]]
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[[Category: Gabelli, S B.]]
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[[Category: Asymmetric dimer]]
[[Category: Asymmetric dimer]]
[[Category: Cdp-choline pyrophosphatase]]
[[Category: Cdp-choline pyrophosphatase]]

Current revision

Crystal structure of CDP-Chase

PDB ID 3q1p

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