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3q90

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==Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1==
==Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1==
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<StructureSection load='3q90' size='340' side='right' caption='[[3q90]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3q90' size='340' side='right'caption='[[3q90]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q90]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q90 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q90]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q90 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q91|3q91]], [[3q93|3q93]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q91|3q91]], [[3q93|3q93]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">G3BP, G3BP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">G3BP, G3BP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q90 OCA], [http://pdbe.org/3q90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q90 RCSB], [http://www.ebi.ac.uk/pdbsum/3q90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q90 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q90 OCA], [https://pdbe.org/3q90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q90 RCSB], [https://www.ebi.ac.uk/pdbsum/3q90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q90 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
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[[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Der]]
[[Category: Berg, S Van Der]]

Revision as of 05:58, 8 June 2022

Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1

PDB ID 3q90

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