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3qak
From Proteopedia
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| - | [[Image:3qak.png|left|200px]] | ||
| - | + | ==Agonist bound structure of the human adenosine A2a receptor== | |
| + | <StructureSection load='3qak' size='340' side='right'caption='[[3qak]], [[Resolution|resolution]] 2.71Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QAK FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=UKA:6-(2,2-DIPHENYLETHYLAMINO)-9-[(2R,3R,4S,5S)-5-(ETHYLCARBAMOYL)-3,4-DIHYDROXY-OXOLAN-2-YL]-N-[2-[(1-PYRIDIN-2-YLPIPERIDIN-4-YL)CARBAMOYLAMINO]ETHYL]PURINE-2-CARBOXAMIDE'>UKA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3eml|3eml]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADORA2, ADORA2A, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qak OCA], [https://pdbe.org/3qak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qak RCSB], [https://www.ebi.ac.uk/pdbsum/3qak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qak ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. We report the crystal structure of the A(2A) adenosine receptor (A(2A)AR) bound to an agonist UK-432097 at 2.7 angstrom resolution. Relative to inactive, antagonist-bound A(2A)AR, the agonist-bound structure displays an outward tilt and rotation of the cytoplasmic half of helix VI, a movement of helix V, and an axial shift of helix III, resembling the changes associated with the active-state opsin structure. Additionally, a seesaw movement of helix VII and a shift of extracellular loop 3 are likely specific to A(2A)AR and its ligand. The results define the molecule UK-432097 as a "conformationally selective agonist" capable of receptor stabilization in a specific active-state configuration. | ||
| - | + | Structure of an agonist-bound human A2A adenosine receptor.,Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC Science. 2011 Apr 15;332(6027):322-7. Epub 2011 Mar 10. PMID:21393508<ref>PMID:21393508</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3qak" style="background-color:#fffaf0;"></div> | |
| - | + | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]] |
| - | *[[ | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
| - | [[Category: Cherezov, V | + | [[Category: Cherezov, V]] |
| - | [[Category: GPCR, GPCR Network | + | [[Category: GPCR, GPCR Network]] |
| - | [[Category: Han, G W | + | [[Category: Han, G W]] |
| - | + | [[Category: Katritch, V]] | |
| - | [[Category: Katritch, V | + | [[Category: Stevens, R]] |
| - | [[Category: Stevens, R | + | [[Category: Wu, H]] |
| - | [[Category: Wu, H | + | [[Category: Xu, F]] |
| - | [[Category: Xu, F | + | |
[[Category: Gpcr]] | [[Category: Gpcr]] | ||
[[Category: Gpcr network]] | [[Category: Gpcr network]] | ||
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[[Category: Joint center for innovative membrane protein technology]] | [[Category: Joint center for innovative membrane protein technology]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
| - | [[Category: Protein structure initiative]] | + | [[Category: PSI, Protein structure initiative]] |
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Current revision
Agonist bound structure of the human adenosine A2a receptor
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Categories: Human | Large Structures | Lysozyme | Cherezov, V | GPCR, GPCR Network | Han, G W | Katritch, V | Stevens, R | Wu, H | Xu, F | Gpcr | Gpcr network | Hydrolase | Jcimpt | Joint center for innovative membrane protein technology | Membrane protein | PSI, Protein structure initiative | Psi-biology | Receptor | Signaling protein | Structural genomic
