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3qb2

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[[Image:3qb2.jpg|left|200px]]
 
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==The Crystal Structure of Immunity Factor for SPN (IFS)==
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The line below this paragraph, containing "STRUCTURE_3qb2", creates the "Structure Box" on the page.
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<StructureSection load='3qb2' size='340' side='right'caption='[[3qb2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qb2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QB2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3qb2| PDB=3qb2 | SCENE= }}
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pnt|3pnt]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ifs ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qb2 OCA], [https://pdbe.org/3qb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qb2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qb2 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The virulence of Gram-positive bacteria is enhanced by toxins like the Streptococcus pyogenes beta-NAD(+) glycohydrolase known as SPN. SPN-producing strains of S. pyogenes additionally express the protein immunity factor for SPN (IFS), which forms an inhibitory complex with SPN. We have determined crystal structures of the SPN-IFS complex and IFS alone, revealing that SPN is structurally related to ADP-ribosyl transferases but lacks the canonical binding site for protein substrates. SPN is instead a highly efficient glycohydrolase with the potential to deplete cellular levels of beta-NAD(+). The protective effect of IFS involves an extensive interaction with the SPN active site that blocks access to beta-NAD(+). The conformation of IFS changes upon binding to SPN, with repacking of an extended C-terminal alpha helix into a compact shape. IFS is an attractive target for the development of novel bacteriocidal compounds functioning by blocking the bacterium's self-immunity to the SPN toxin.
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===The Crystal Structure of Immunity Factor for SPN (IFS)===
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Structural Basis of Streptococcus pyogenes Immunity to Its NAD(+) Glycohydrolase Toxin.,Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T Structure. 2011 Feb 9;19(2):192-202. PMID:21300288<ref>PMID:21300288</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qb2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21300288 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21300288}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Micrococcus scarlatinae klein 1884]]
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[[3qb2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB2 OCA].
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[[Category: Large Structures]]
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[[Category: Ellenberger, T]]
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==Reference==
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[[Category: Smith, C L]]
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<ref group="xtra">PMID:21300288</ref><references group="xtra"/>
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[[Category: Glycohydrolase inhibitor]]
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[[Category: Streptococcus pyogenes]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Ellenberger, T.]]
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[[Category: Streptococcus pyogenes glycohydrolase toxin]]
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[[Category: Smith, C L.]]
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Current revision

The Crystal Structure of Immunity Factor for SPN (IFS)

PDB ID 3qb2

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