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3qt2
From Proteopedia
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| - | [[Image:3qt2.jpg|left|200px]] | ||
| - | < | + | ==Structure of a cytokine ligand-receptor complex== |
| - | + | <StructureSection load='3qt2' size='340' side='right'caption='[[3qt2]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qt2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QT2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
| - | -- | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL5R, IL5RA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qt2 OCA], [https://pdbe.org/3qt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qt2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qt2 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/IL5RA_HUMAN IL5RA_HUMAN]] This is the receptor for interleukin-5. The alpha chain binds to IL5. [[https://www.uniprot.org/uniprot/IL5_HUMAN IL5_HUMAN]] Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interleukin-5 (IL-5) is the key mediator for the function of eosinophil granulocytes, whose deregulation is characteristic of hypereosinophilic diseases and presumably contributes to allergic asthma. IL-5 signaling involves two transmembrane receptors, IL-5Ralpha and the common beta chain, which upon formation of the ternary complex activate the JAK/STAT signaling cascade. To investigate the mechanism underlying ligand-receptor recognition, we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. IL-5 makes contact with all three fibronectin III-like domains of IL-5Ralpha, with the receptor architecture resembling a wrench. Mutagenesis data provide evidence that this wrench-like architecture is likely preformed. The structure demonstrates that for steric reasons, homodimeric IL-5 can bind only one receptor molecule, even though two equivalent receptor-binding sites exist. In regard to strong efforts being made to develop IL-5 antagonists for treating asthma and hypereosinophilic diseases, the advances in molecular understanding provided by this structure are of greatest value. | ||
| - | + | Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha.,Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD Structure. 2011 Dec 7;19(12):1864-75. PMID:22153509<ref>PMID:22153509</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3qt2" style="background-color:#fffaf0;"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
| - | + | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | [[ | + | [[Category: Human]] |
| - | + | [[Category: Large Structures]] | |
| - | == | + | [[Category: Kotzsch, A]] |
| - | < | + | [[Category: Mueller, T D]] |
| - | [[Category: | + | [[Category: Nickel, J]] |
| - | [[Category: Kotzsch, A | + | [[Category: Patino, E]] |
| - | [[Category: Mueller, T D | + | [[Category: Saremba, S]] |
| - | [[Category: Nickel, J | + | [[Category: Schmitz, W]] |
| - | [[Category: Patino, E | + | [[Category: Sebald, W]] |
| - | [[Category: Saremba, S | + | |
| - | [[Category: Schmitz, W | + | |
| - | [[Category: Sebald, W | + | |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Cytokine type i receptor fold]] | [[Category: Cytokine type i receptor fold]] | ||
Current revision
Structure of a cytokine ligand-receptor complex
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