This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3raf
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3raf.png|left|200px]] | ||
| - | + | ==Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae== | |
| - | + | <StructureSection load='3raf' size='340' side='right'caption='[[3raf]], [[Resolution|resolution]] 3.24Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3raf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDQ:3-AMINO-7-{(3R)-3-[(1S)-1-AMINOETHYL]PYRROLIDIN-1-YL}-1-CYCLOPROPYL-6-FLUORO-8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE'>PDQ</scene></td></tr> | |
| - | == | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nov|2nov]], [[3foe|3foe]], [[3fof|3fof]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]]</div></td></tr> |
| - | [[3raf]] is a 8 chain structure with sequence from [ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ParC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886]), ParE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3raf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raf OCA], [https://pdbe.org/3raf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3raf RCSB], [https://www.ebi.ac.uk/pdbsum/3raf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3raf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[https://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Topoisomerase|Topoisomerase]] | + | *[[Topoisomerase 3D structures|Topoisomerase 3D structures]] |
| - | [[Category: | + | == References == |
| - | [[Category: Fisher, L M | + | <references/> |
| - | [[Category: Laponogov, I | + | __TOC__ |
| - | [[Category: McAuley, K E | + | </StructureSection> |
| - | [[Category: Pan, X S | + | [[Category: Large Structures]] |
| - | [[Category: Sanderson, M R | + | [[Category: Fisher, L M]] |
| - | [[Category: Veselkov, D A | + | [[Category: Laponogov, I]] |
| + | [[Category: McAuley, K E]] | ||
| + | [[Category: Pan, X S]] | ||
| + | [[Category: Sanderson, M R]] | ||
| + | [[Category: Veselkov, D A]] | ||
[[Category: Isomerase-dna-antibiotic complex]] | [[Category: Isomerase-dna-antibiotic complex]] | ||
[[Category: Protein-dna cleavage complex]] | [[Category: Protein-dna cleavage complex]] | ||
[[Category: Quinazolinedione pd 0305970]] | [[Category: Quinazolinedione pd 0305970]] | ||
[[Category: Topoisomerase iia]] | [[Category: Topoisomerase iia]] | ||
Current revision
Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae
| |||||||||||
