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UMP/CMP kinase

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Current revision (08:11, 20 June 2022) (edit) (undo)
 
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<StructureSection load='5kud' size='350' side='right' caption='Structure of UMP/CMP kinase complex with SDP and CMP (PDB entry [[5kud]])' scene=''>
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<StructureSection load='1tev' size='350' side='right' caption='Structure of human UMP/CMP kinase complex with sulfate (PDB entry [[1tev]])' scene='69/698098/Cv/1'>
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__TOC__
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== Function ==
== Function ==
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== Relevance ==
== Relevance ==
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everal cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
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Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
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== Structural highlights ==
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</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1tev]], [[7e9v]] – UCK – human <br />
[[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br />
[[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br />
[[4ukd]] – smUCK + ADP + UDP <br />
[[4ukd]] – smUCK + ADP + UDP <br />
[[1uke]] – smUCK + inhibitor<br />
[[1uke]] – smUCK + inhibitor<br />
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[[1tev]] – UCK – human <br />
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human UMP/CMP kinase complex with sulfate (PDB entry 1tev)

Drag the structure with the mouse to rotate

3D Structures of UMP/CMP kinase

Updated on 20-June-2022

1tev, 7e9v – UCK – human
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor


References

  1. ↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
  2. ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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