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2n09
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2n09 is ON HOLD Authors: Hoang, H. Description: structure for 11mer in H2O/DMSO Category: Unreleased Structures Category: Hoang, H) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of a short hydrophobic 11mer peptide in DMSO-d6/H2O (1:3) solution== | |
| + | <StructureSection load='2n09' size='340' side='right'caption='[[2n09]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n09]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N09 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n08|2n08]], [[2n0i|2n0i]], [[2n0n|2n0n]]</div></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n09 OCA], [https://pdbe.org/2n09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n09 RCSB], [https://www.ebi.ac.uk/pdbsum/2n09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n09 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cyclic constraints are incorporated here into an 11-residue analogue of the N-terminus of glucagon-like peptide-1 (GLP-1) to investigate effects of structure on agonist activity. Cyclization through linking side chains of residues 2 and 5 or 5 and 9 produced agonists at nM concentrations in a cAMP assay. 2D-NMR and CD spectra revealed an N-terminal beta-turn and a C-terminal helix that differentially influenced affinity and agonist potency. These structures can inform development of small molecule agonists of the GLP-1 receptor to treat type 2 diabetes. | ||
| - | + | Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists.,Hoang HN, Song K, Hill TA, Derksen DR, Edmonds DJ, Kok WM, Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM, Piotrowski DW, Price DA, Stanton RV, Suen JY, Withka JM, Griffith DA, Fairlie DP J Med Chem. 2015 Apr 3. PMID:25839426<ref>PMID:25839426</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Hoang, H]] | + | <div class="pdbe-citations 2n09" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Derksen, D R]] | ||
| + | [[Category: Edmonds, D J]] | ||
| + | [[Category: Fairlie, D P]] | ||
| + | [[Category: Griffith, D A]] | ||
| + | [[Category: Hill, T A]] | ||
| + | [[Category: Hoang, H N]] | ||
| + | [[Category: Kok, W M]] | ||
| + | [[Category: Limberakis, C]] | ||
| + | [[Category: Liras, S]] | ||
| + | [[Category: Loria, P M]] | ||
| + | [[Category: Mascitti, V]] | ||
| + | [[Category: Mathiowetz, A M]] | ||
| + | [[Category: Mitchell, J M]] | ||
| + | [[Category: Piotrowski, D W]] | ||
| + | [[Category: Price, D A]] | ||
| + | [[Category: Song, K]] | ||
| + | [[Category: Stanton, R V]] | ||
| + | [[Category: Suen, J Y]] | ||
| + | [[Category: Withka, J M]] | ||
| + | [[Category: De novo protein]] | ||
| + | [[Category: Glp-1r agonist]] | ||
| + | [[Category: Hydrophobic peptide]] | ||
Current revision
NMR structure of a short hydrophobic 11mer peptide in DMSO-d6/H2O (1:3) solution
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Categories: Large Structures | Derksen, D R | Edmonds, D J | Fairlie, D P | Griffith, D A | Hill, T A | Hoang, H N | Kok, W M | Limberakis, C | Liras, S | Loria, P M | Mascitti, V | Mathiowetz, A M | Mitchell, J M | Piotrowski, D W | Price, D A | Song, K | Stanton, R V | Suen, J Y | Withka, J M | De novo protein | Glp-1r agonist | Hydrophobic peptide
