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2xzb

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[[Image:2xzb.jpg|left|200px]]
 
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==Pig Gastric H,K-ATPase with bound BeF and SCH28080==
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The line below this paragraph, containing "STRUCTURE_2xzb", creates the "Structure Box" on the page.
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<StructureSection load='2xzb' size='340' side='right'caption='[[2xzb]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3a3y|3a3y]], [[1iwc|1iwc]], [[1iwf|1iwf]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
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{{STRUCTURE_2xzb| PDB=2xzb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzb OCA], [https://pdbe.org/2xzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xzb RCSB], [https://www.ebi.ac.uk/pdbsum/2xzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xzb ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.
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== Function ==
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[[https://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Acid-related gastric diseases are associated with disorder of digestive tract acidification. The gastric proton pump, H(+),K(+)-ATPase, exports H(+) in exchange for luminal K(+) to generate a highly acidic environment in the stomach, and is a main target for acid suppressants. Here, we report the three-dimensional structure of gastric H(+),K(+)-ATPase with bound SCH28080, a representative K(+)-competitive acid blocker, at 7 A resolution based on electron crystallography of two-dimensional crystals. The density of the bound SCH28080 is found near transmembrane (TM) helices 4, 5 and 6, in the luminal cavity. The SCH28080-binding site is formed by the rearrangement of TM helices, which is in turn transmitted to the cytoplasmic domains, resulting in a luminal-open conformation. These results represent the first structural evidence for a binding site of an acid suppressant on H(+),K(+)-ATPase, and the conformational change induced by this class of drugs.
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===PIG GASTRIC H,K-ATPASE WITH BOUND BEF AND SCH28080===
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Conformational rearrangement of gastric H(+),K(+)-ATPase induced by an acid suppressant.,Abe K, Tani K, Fujiyoshi Y Nat Commun. 2011 Jan;2(1):155. PMID:21224846<ref>PMID:21224846</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2xzb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21224846}}, adds the Publication Abstract to the page
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*[[ATPase 3D structures|ATPase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21224846 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21224846}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2xzb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZB OCA].
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==Reference==
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<ref group="xtra">PMID:21224846</ref><references group="xtra"/>
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[[Category: Hydrogen/potassium-exchanging ATPase]]
[[Category: Hydrogen/potassium-exchanging ATPase]]
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Abe, K.]]
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[[Category: Abe, K]]
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[[Category: Fujiyoshi, Y.]]
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[[Category: Fujiyoshi, Y]]
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[[Category: Tani, K.]]
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[[Category: Tani, K]]
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[[Category: Acid suppressant]]
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[[Category: Atp-binding]]
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[[Category: Beryllium fluoride]]
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[[Category: H/k-atpase]]
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[[Category: Hydrolase]]
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[[Category: Ion pump]]
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[[Category: Membrane protein]]
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[[Category: P-type atpase]]

Current revision

Pig Gastric H,K-ATPase with bound BeF and SCH28080

PDB ID 2xzb

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