This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3s32

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:35, 22 June 2022) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3s32.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of Ash2L N-terminal domain==
-
The line below this paragraph, containing "STRUCTURE_3s32", creates the "Structure Box" on the page.
+
<StructureSection load='3s32' size='340' side='right'caption='[[3s32]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3s32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S32 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
-->
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_3s32| PDB=3s32 | SCENE= }}
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s32 OCA], [https://pdbe.org/3s32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s32 RCSB], [https://www.ebi.ac.uk/pdbsum/3s32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s32 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN]] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the beta-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the beta-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain.
-
===Crystal structure of Ash2L N-terminal domain===
+
Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.,Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9. doi: 10.1038/nsmb.2093. PMID:21642971<ref>PMID:21642971</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3s32" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[3s32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA].
+
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-
[[Category: Homo sapiens]]
+
== References ==
-
[[Category: Avdic, V.]]
+
<references/>
-
[[Category: Blais, A.]]
+
__TOC__
-
[[Category: Brand, M.]]
+
</StructureSection>
-
[[Category: Brunzelle, J S.]]
+
[[Category: Human]]
-
[[Category: Chaturvedi, C P.]]
+
[[Category: Large Structures]]
-
[[Category: Couture, J F.]]
+
[[Category: Avdic, V]]
-
[[Category: Lanouette, S.]]
+
[[Category: Blais, A]]
-
[[Category: Sarvan, S.]]
+
[[Category: Brand, M]]
-
[[Category: Tremblay, V.]]
+
[[Category: Brunzelle, J S]]
-
[[Category: Zhang, P.]]
+
[[Category: Chaturvedi, C P]]
 +
[[Category: Couture, J F]]
 +
[[Category: Lanouette, S]]
 +
[[Category: Sarvan, S]]
 +
[[Category: Tremblay, V]]
 +
[[Category: Zhang, P]]
 +
[[Category: C4-zinc finger]]
 +
[[Category: Chromatin]]
 +
[[Category: Helix-wing-helix]]
 +
[[Category: Histone]]
 +
[[Category: Myeloid lymphoma leukemia protein]]
 +
[[Category: Nucleus]]
 +
[[Category: Transcription]]
 +
[[Category: Trithorax]]
 +
[[Category: Trithorax group protein]]

Current revision

Crystal structure of Ash2L N-terminal domain

PDB ID 3s32

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3s32"
Personal tools