This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3sxd
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of BBBB+UDP+Gal with MPD as the cryoprotectant== | ==Crystal structure of BBBB+UDP+Gal with MPD as the cryoprotectant== | ||
| - | <StructureSection load='3sxd' size='340' side='right' caption='[[3sxd]], [[Resolution|resolution]] 1.55Å' scene=''> | + | <StructureSection load='3sxd' size='340' side='right'caption='[[3sxd]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3sxd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3sxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. The December 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''ABO Blood Type Glycosyltransferases'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_12 10.2210/rcsb_pdb/mom_2012_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SXD FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sx3|3sx3]], [[3sx5|3sx5]], [[3sx7|3sx7]], [[3sx8|3sx8]], [[3sxa|3sxa]], [[3sxb|3sxb]], [[3sxc|3sxc]], [[3sxe|3sxe]], [[3sxg|3sxg]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sx3|3sx3]], [[3sx5|3sx5]], [[3sx7|3sx7]], [[3sx8|3sx8]], [[3sxa|3sxa]], [[3sxb|3sxb]], [[3sxc|3sxc]], [[3sxe|3sxe]], [[3sxg|3sxg]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxd OCA], [https://pdbe.org/3sxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sxd RCSB], [https://www.ebi.ac.uk/pdbsum/3sxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxd ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 23: | ||
==See Also== | ==See Also== | ||
| - | *[[Glycosyltransferase|Glycosyltransferase]] | + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 31: | Line 31: | ||
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]] | [[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Evans, S V]] | [[Category: Evans, S V]] | ||
Revision as of 08:14, 29 June 2022
Crystal structure of BBBB+UDP+Gal with MPD as the cryoprotectant
| |||||||||||
Categories: ABO Blood Type Glycosyltransferases | Fucosylgalactoside 3-alpha-galactosyltransferase | Human | Large Structures | RCSB PDB Molecule of the Month | Evans, S V | Johal, A R | Abo rossmann fold | Blood group antigen | Glycoprotein | Manganese | Metal-binding | Retaining glycosyltransferase | Transferase
