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Siroheme synthase
From Proteopedia
(New page: <StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code 6p5z) ' scene=''> Th...) |
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| - | + | <StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex with Co-sirohydrochlorin, SAH and Cl- ion (PDB code [[6p5z]]) ' scene='91/915831/Cv/2'> | |
| - | <StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex | + | |
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== Function == | == Function == | ||
| - | + | '''Siroheme synthase''' (CysG) catalyzes the reduction of sulfite to sulfide or nitrite to ammonia<ref>PMId:32054833</ref>. CysG substrate is a tetrapyrrole. | |
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== Structural highlights == | == Structural highlights == | ||
| - | + | The tetrapyrrole in siroheme is heavily negatively charged because of the 8 acetyl and propionyl carboxylates at the corners of the siroheme and it interacts with <scene name='91/915831/Cv/6'>residues of subunits A and B</scene>. Five of these residues are positively charged <scene name='91/915831/Cv/7'>Arg and Lys residues</scene>. | |
</StructureSection> | </StructureSection> | ||
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| + | ==Siroheme synthase 3D structures== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | [[1pjq]] – StCysG + SAH – ''Salmonella typhimurium''<BR /> | ||
| + | [[1pjt]], [[6p7c]], [[6p7d]], [[6pqz]], [[6pr0]], [[6pr1]], [[6pr2]], [[6pr3]], [[6pr4]], [[6ulu]] – StCysG (mutant) + SAH <BR /> | ||
| + | [[6p5z]] – StCysG + SAH + Co-sirohydrochlorin <BR /> | ||
| + | [[1pjs]] – StCysG + SAH + NAD <BR /> | ||
| + | [[6p5x]] – StCysG (mutant) + SAH + substrate<BR /> | ||
| + | [[6veb]] – StCysG (mutant) + SAH + NAD + pecorrin<BR /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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Siroheme synthase 3D structures
Updated on 03-July-2022
1pjq – StCysG + SAH – Salmonella typhimurium
1pjt, 6p7c, 6p7d, 6pqz, 6pr0, 6pr1, 6pr2, 6pr3, 6pr4, 6ulu – StCysG (mutant) + SAH
6p5z – StCysG + SAH + Co-sirohydrochlorin
1pjs – StCysG + SAH + NAD
6p5x – StCysG (mutant) + SAH + substrate
6veb – StCysG (mutant) + SAH + NAD + pecorrin
References
- ↑ Pennington JM, Kemp M, McGarry L, Chen Y, Stroupe ME. Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun. 2020 Feb 13;11(1):864. doi: 10.1038/s41467-020-14722-1. PMID:32054833 doi:http://dx.doi.org/10.1038/s41467-020-14722-1
