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3t1f

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[[Image:3t1f.png|left|200px]]
 
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==Crystal structure of the mouse CD1d-Glc-DAG-s2 complex==
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The line below this paragraph, containing "STRUCTURE_3t1f", creates the "Structure Box" on the page.
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<StructureSection load='3t1f' size='340' side='right'caption='[[3t1f]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T1F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TF:(2S)-1-(ALPHA-D-GLUCOPYRANOSYLOXY)-3-(HEXADECANOYLOXY)PROPAN-2-YL+(11Z)-OCTADEC-11-ENOATE'>3TF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1.1, Cd1d1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m, beta-2-microglobulin ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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{{STRUCTURE_3t1f| PDB=3t1f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t1f OCA], [https://pdbe.org/3t1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t1f RCSB], [https://www.ebi.ac.uk/pdbsum/3t1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t1f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.
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===Crystal structure of the mouse CD1d-Glc-DAG-s2 complex===
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Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.,Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gomez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M Nat Immunol. 2011 Sep 4. doi: 10.1038/ni.2096. PMID:21892173<ref>PMID:21892173</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t1f" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21892173}}, adds the Publication Abstract to the page
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21892173 is the PubMed ID number.
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*[[CD1|CD1]]
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== References ==
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{{ABSTRACT_PUBMED_21892173}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3t1f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1F OCA].
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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==Reference==
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[[Category: Girardi, E]]
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<ref group="xtra">PMID:021892173</ref><references group="xtra"/>
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[[Category: Zajonc, D M]]
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[[Category: Mus musculus]]
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[[Category: Girardi, E.]]
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[[Category: Zajonc, D M.]]
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[[Category: Antigen presentation]]
[[Category: Antigen presentation]]
[[Category: Glycolipid]]
[[Category: Glycolipid]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Nkt cell]]
[[Category: Nkt cell]]

Current revision

Crystal structure of the mouse CD1d-Glc-DAG-s2 complex

PDB ID 3t1f

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