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3te6

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==Crystal Structure of the S. cerevisiae Sir3 AAA+ domain==
==Crystal Structure of the S. cerevisiae Sir3 AAA+ domain==
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<StructureSection load='3te6' size='340' side='right' caption='[[3te6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3te6' size='340' side='right'caption='[[3te6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3te6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TE6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3te6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TE6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fvu|2fvu]], [[2fl7|2fl7]], [[1nyh|1nyh]], [[3owt|3owt]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fvu|2fvu]], [[2fl7|2fl7]], [[1nyh|1nyh]], [[3owt|3owt]]</div></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIR3, CMT1, MAR2, STE8, YLR442C, L9753.10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIR3, CMT1, MAR2, STE8, YLR442C, L9753.10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3te6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3te6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3te6 RCSB], [http://www.ebi.ac.uk/pdbsum/3te6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3te6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3te6 OCA], [https://pdbe.org/3te6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3te6 RCSB], [https://www.ebi.ac.uk/pdbsum/3te6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3te6 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.,Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE Genes Dev. 2011 Sep 1;25(17):1835-46. PMID:21896656<ref>PMID:21896656</ref>
Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.,Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE Genes Dev. 2011 Sep 1;25(17):1835-46. PMID:21896656<ref>PMID:21896656</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3te6" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Baker's yeast]]
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[[Category: Hassler, M.]]
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[[Category: Large Structures]]
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[[Category: Ladurner, A G.]]
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[[Category: Hassler, M]]
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[[Category: Ladurner, A G]]
[[Category: Aaa+ domain]]
[[Category: Aaa+ domain]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]

Current revision

Crystal Structure of the S. cerevisiae Sir3 AAA+ domain

PDB ID 3te6

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