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3tk5

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'''Unreleased structure'''
 
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The entry 3tk5 is ON HOLD
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==Factor Xa in complex with D102-4380==
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<StructureSection load='3tk5' size='340' side='right'caption='[[3tk5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TK5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D1Q:4-{3-[(4-CHLOROPHENYL)AMINO]-3-OXOPROPYL}-3-({[5-(PROPAN-2-YL)-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-YL]CARBONYL}AMINO)BENZOIC+ACID'>D1Q</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ei6|2ei6]], [[2ei7|2ei7]], [[2ei8|2ei8]], [[1v3x|1v3x]], [[1wu1|1wu1]], [[2d1j|2d1j]], [[3tk6|3tk6]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk5 OCA], [https://pdbe.org/3tk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tk5 RCSB], [https://www.ebi.ac.uk/pdbsum/3tk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk5 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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Authors: Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
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==See Also==
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*[[Factor Xa|Factor Xa]]
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Description: Factor Xa in complex with D102-4380
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Coagulation factor Xa]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kanno, H]]
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[[Category: Kishida, M]]
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[[Category: Mochizuki, A]]
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[[Category: Nagata, T]]
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[[Category: Ohta, T]]
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[[Category: Suzuki, M]]
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[[Category: Takano, H]]
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[[Category: Blood]]
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[[Category: Calcium-binding]]
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[[Category: Coagulation factor]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Plasma]]
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[[Category: Serine protease]]

Current revision

Factor Xa in complex with D102-4380

PDB ID 3tk5

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