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3tk6
From Proteopedia
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| - | [[Image:3tk6.jpg|left|200px]] | ||
| - | + | ==factor Xa in complex with D46-5241== | |
| + | <StructureSection load='3tk6' size='340' side='right'caption='[[3tk6]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TK6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D46:N-[2-({[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}METHYL)PHENYL]-5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE'>D46</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ei6|2ei6]], [[2ei7|2ei7]], [[2ei8|2ei8]], [[1v3x|1v3x]], [[1wu1|1wu1]], [[2d1j|2d1j]], [[3tk5|3tk5]]</div></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [https://pdbe.org/3tk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. | ||
| - | == | + | ==See Also== |
| - | + | *[[Factor Xa|Factor Xa]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Coagulation factor Xa]] | [[Category: Coagulation factor Xa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Kanno, H | + | [[Category: Large Structures]] |
| - | [[Category: Kishida, M | + | [[Category: Kanno, H]] |
| - | [[Category: Mochizuki, A | + | [[Category: Kishida, M]] |
| - | [[Category: Nagata, T | + | [[Category: Mochizuki, A]] |
| - | [[Category: Ohta, T | + | [[Category: Nagata, T]] |
| - | [[Category: Suzuki, M | + | [[Category: Ohta, T]] |
| - | [[Category: Takano, H | + | [[Category: Suzuki, M]] |
| + | [[Category: Takano, H]] | ||
[[Category: Blood]] | [[Category: Blood]] | ||
[[Category: Calcium-binding]] | [[Category: Calcium-binding]] | ||
Current revision
factor Xa in complex with D46-5241
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