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3ub5

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[[Image:3ub5.jpg|left|200px]]
 
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==Profilin:actin with a wide open nucleotide cleft==
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The line below this paragraph, containing "STRUCTURE_3ub5", creates the "Structure Box" on the page.
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<StructureSection load='3ub5' size='340' side='right'caption='[[3ub5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ub5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UB5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_3ub5| PDB=3ub5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ub5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub5 OCA], [https://pdbe.org/3ub5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ub5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ub5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ub5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[https://www.uniprot.org/uniprot/PROF1_BOVIN PROF1_BOVIN]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Actin is a ubiquitous eukaryotic protein that is responsible for cellular scaffolding, motility, and division. The ability of actin to form a helical filament is the driving force behind these cellular activities. Formation of a filament depends on the successful exchange of actin's ADP for ATP. Mammalian profilin is a small actin binding protein that catalyzes the exchange of nucleotide and facilitates the addition of an actin monomer to a growing filament. Here, crystal structures of profilin-actin have been determined to show an actively exchanging ATP. Structural analysis shows how the binding of profilin to the barbed end of actin causes a rotation of the small domain relative to the large domain. This conformational change is propagated to the ATP site and causes a shift in nucleotide loops, which in turn causes a repositioning of Ca(2+) to its canonical position as the cleft closes around ATP. Reversal of the solvent exposure of Trp356 is also involved in cleft closure. In addition, secondary calcium binding sites were identified.
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===Profilin:actin with a wide open nucleotide cleft===
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Structural basis for profilin-mediated actin nucleotide exchange.,Porta JC, Borgstahl GE J Mol Biol. 2012 Apr 20;418(1-2):103-16. Epub 2012 Feb 22. PMID:22366544<ref>PMID:22366544</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ub5" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22366544}}, adds the Publication Abstract to the page
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*[[Actin 3D structures|Actin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22366544 is the PubMed ID number.
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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== References ==
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{{ABSTRACT_PUBMED_22366544}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3ub5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB5 OCA].
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==Reference==
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<ref group="xtra">PMID:022366544</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Borgstahl, G E.]]
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[[Category: Large Structures]]
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[[Category: Porta, J C.]]
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[[Category: Borgstahl, G E]]
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[[Category: Porta, J C]]
[[Category: Atpase]]
[[Category: Atpase]]
[[Category: Nucleotide exchange]]
[[Category: Nucleotide exchange]]
[[Category: Structural protein]]
[[Category: Structural protein]]

Current revision

Profilin:actin with a wide open nucleotide cleft

PDB ID 3ub5

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