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3udl
From Proteopedia
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==3-heterocyclyl quinolone bound to HCV NS5B== | ==3-heterocyclyl quinolone bound to HCV NS5B== | ||
| - | <StructureSection load='3udl' size='340' side='right' caption='[[3udl]], [[Resolution|resolution]] 2.17Å' scene=''> | + | <StructureSection load='3udl' size='340' side='right'caption='[[3udl]], [[Resolution|resolution]] 2.17Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3udl]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3udl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDL FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KLI:3-(5-BENZYL-1,2,4-OXADIAZOL-3-YL)-6-FLUORO-1-[2-FLUORO-4-(TRIFLUOROMETHYL)BENZYL]-7-(4-METHYLPIPERAZIN-1-YL)QUINOLIN-4(1H)-ONE'>KLI</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KLI:3-(5-BENZYL-1,2,4-OXADIAZOL-3-YL)-6-FLUORO-1-[2-FLUORO-4-(TRIFLUOROMETHYL)BENZYL]-7-(4-METHYLPIPERAZIN-1-YL)QUINOLIN-4(1H)-ONE'>KLI</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udl OCA], [https://pdbe.org/3udl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3udl RCSB], [https://www.ebi.ac.uk/pdbsum/3udl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3udl ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Quinolones as HCV NS5B polymerase inhibitors.,Kumar DV, Rai R, Brameld KA, Somoza JR, Rajagopalan R, Janc JW, Xia YM, Ton TL, Shaghafi MB, Hu H, Lehoux I, To N, Young WB, Green MJ Bioorg Med Chem Lett. 2011 Jan 1;21(1):82-7. Epub 2010 Nov 21. PMID:21145235<ref>PMID:21145235</ref> | Quinolones as HCV NS5B polymerase inhibitors.,Kumar DV, Rai R, Brameld KA, Somoza JR, Rajagopalan R, Janc JW, Xia YM, Ton TL, Shaghafi MB, Hu H, Lehoux I, To N, Young WB, Green MJ Bioorg Med Chem Lett. 2011 Jan 1;21(1):82-7. Epub 2010 Nov 21. PMID:21145235<ref>PMID:21145235</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3udl" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[RNA polymerase|RNA polymerase]] | + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Hepatitis c virus subtype 1b]] | [[Category: Hepatitis c virus subtype 1b]] | ||
| - | [[Category: Somoza, J R | + | [[Category: Large Structures]] |
| + | [[Category: Somoza, J R]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Hcv]] | [[Category: Hcv]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Polymerase]] | [[Category: Polymerase]] | ||
Current revision
3-heterocyclyl quinolone bound to HCV NS5B
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