1hqc

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[[Image:1hqc.gif|left|200px]]
[[Image:1hqc.gif|left|200px]]
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{{Structure
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|PDB= 1hqc |SIZE=350|CAPTION= <scene name='initialview01'>1hqc</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1hqc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= RUVB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
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|DOMAIN=
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{{STRUCTURE_1hqc| PDB=1hqc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqc OCA], [http://www.ebi.ac.uk/pdbsum/1hqc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hqc RCSB]</span>
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'''STRUCTURE OF RUVB FROM THERMUS THERMOPHILUS HB8'''
'''STRUCTURE OF RUVB FROM THERMUS THERMOPHILUS HB8'''
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[[Category: Morikawa, K.]]
[[Category: Morikawa, K.]]
[[Category: Yamada, K.]]
[[Category: Yamada, K.]]
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[[Category: complex with nucleotide]]
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[[Category: Complex with nucleotide]]
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[[Category: extended aaa-atpase domain]]
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[[Category: Extended aaa-atpase domain]]
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[[Category: ruvb]]
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[[Category: Ruvb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:07:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:00 2008''
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Revision as of 16:07, 2 May 2008

Image:1hqc.gif

Template:STRUCTURE 1hqc

STRUCTURE OF RUVB FROM THERMUS THERMOPHILUS HB8


Overview

We report here the crystal structure of the RuvB motor protein from Thermus thermophilus HB8, which drives branch migration of the Holliday junction during homologous recombination. RuvB has a crescent-like architecture consisting of three consecutive domains, the first two of which are involved in ATP binding and hydrolysis. DNA is likely to interact with a large basic cleft, which encompasses the ATP-binding pocket and domain boundaries, whereas the junction-recognition protein RuvA may bind a flexible beta-hairpin protruding from the N-terminal domain. The structures of two subunits, related by a noncrystallographic pseudo-2-fold axis, imply that conformational changes of motor protein coupled with ATP hydrolysis may reflect motility essential for its translocation around double-stranded DNA.

About this Structure

1HQC is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8., Yamada K, Kunishima N, Mayanagi K, Ohnishi T, Nishino T, Iwasaki H, Shinagawa H, Morikawa K, Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1442-7. Epub 2001 Feb 6. PMID:11171970 Page seeded by OCA on Fri May 2 19:07:15 2008

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