This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7wih
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Cryo-EM structure of LY2794193-bound mGlu3== | ==Cryo-EM structure of LY2794193-bound mGlu3== | ||
| - | <StructureSection load='7wih' size='340' side='right'caption='[[7wih]]' scene=''> | + | <StructureSection load='7wih' size='340' side='right'caption='[[7wih]], [[Resolution|resolution]] 3.68Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIH FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIH FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wih OCA], [https://pdbe.org/7wih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wih RCSB], [https://www.ebi.ac.uk/pdbsum/7wih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wih ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWY:(1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic+acid'>CWY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wih OCA], [https://pdbe.org/7wih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wih RCSB], [https://www.ebi.ac.uk/pdbsum/7wih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wih ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fang W]] | + | [[Category: Fang, W]] |
| - | [[Category: Lin L]] | + | [[Category: Lin, L]] |
| - | [[Category: Ling | + | [[Category: Ling, S L]] |
| - | [[Category: Liu | + | [[Category: Liu, J F]] |
| - | [[Category: Liu P]] | + | [[Category: Liu, P]] |
| - | [[Category: Pan S]] | + | [[Category: Pan, S]] |
| - | [[Category: Pin | + | [[Category: Pin, J P]] |
| - | [[Category: Rondard P]] | + | [[Category: Rondard, P]] |
| - | [[Category: Sun | + | [[Category: Sun, W J]] |
| - | [[Category: Tian | + | [[Category: Tian, C L]] |
| - | [[Category: Wang | + | [[Category: Wang, X M]] |
| - | [[Category: Xu | + | [[Category: Xu, C J]] |
| - | [[Category: Yang F]] | + | [[Category: Yang, F]] |
| - | [[Category: Zhou | + | [[Category: Zhou, Y X]] |
| + | [[Category: Cryo-em]] | ||
| + | [[Category: G protein-coupled receptor]] | ||
| + | [[Category: Glutamate]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Selective ligand]] | ||
Revision as of 07:19, 20 July 2022
Cryo-EM structure of LY2794193-bound mGlu3
| |||||||||||
Categories: Large Structures | Fang, W | Lin, L | Ling, S L | Liu, J F | Liu, P | Pan, S | Pin, J P | Rondard, P | Sun, W J | Tian, C L | Wang, X M | Xu, C J | Yang, F | Zhou, Y X | Cryo-em | G protein-coupled receptor | Glutamate | Membrane protein | Selective ligand
