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3v47
From Proteopedia
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| - | [[Image:3v47.png|left|200px]] | ||
| - | < | + | ==Crystal structure of the N-terminal fragment of zebrafish TLR5 in complex with Salmonella flagellin== |
| - | + | <StructureSection load='3v47' size='340' side='right'caption='[[3v47]], [[Resolution|resolution]] 2.47Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3v47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri] and [https://en.wikipedia.org/wiki/Saldu Saldu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V47 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | -- | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v44|3v44]]</div></td></tr> |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fliC, fliC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=98360 SALDU])</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v47 OCA], [https://pdbe.org/3v47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v47 RCSB], [https://www.ebi.ac.uk/pdbsum/3v47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v47 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/FLIC_SALDU FLIC_SALDU]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates signaling through the transcription factor NF-kappaB and triggers an innate immune response to the invading pathogen. To elucidate the structural basis and mechanistic implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, at 2.47 angstrom resolution. TLR5 interacts primarily with the three helices of the FliC D1 domain using its lateral side. Two TLR5-FliC 1:1 heterodimers assemble into a 2:2 tail-to-tail signaling complex that is stabilized by quaternary contacts of the FliC D1 domain with the convex surface of the opposing TLR5. The proposed signaling mechanism is supported by structure-guided mutagenesis and deletion analyses on CBLB502, a therapeutic protein derived from FliC. | ||
| - | + | Structural basis of TLR5-flagellin recognition and signaling.,Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA Science. 2012 Feb 17;335(6070):859-64. PMID:22344444<ref>PMID:22344444</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3v47" style="background-color:#fffaf0;"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Flagellin|Flagellin]] | |
| - | + | *[[Flagellin 3D structures|Flagellin 3D structures]] | |
| - | + | *[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] | |
| - | + | *[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[ | + | __TOC__ |
| - | + | </StructureSection> | |
| - | == | + | [[Category: Bdellostoma burgeri]] |
| - | < | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Saldu]] |
| - | [[Category: | + | [[Category: Hong, H]] |
| - | [[Category: Hong, H | + | [[Category: Wilson, I A]] |
| - | [[Category: Wilson, I A | + | [[Category: Yoon, S I]] |
| - | [[Category: Yoon, S I | + | |
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Innate immune receptor]] | [[Category: Innate immune receptor]] | ||
[[Category: Innate immunity]] | [[Category: Innate immunity]] | ||
[[Category: Leucine-rich repeat]] | [[Category: Leucine-rich repeat]] | ||
Current revision
Crystal structure of the N-terminal fragment of zebrafish TLR5 in complex with Salmonella flagellin
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