3v8d
From Proteopedia
(Difference between revisions)
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==Crystal structure of human CYP7A1 in complex with 7-ketocholesterol== | ==Crystal structure of human CYP7A1 in complex with 7-ketocholesterol== | ||
| - | <StructureSection load='3v8d' size='340' side='right' caption='[[3v8d]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3v8d' size='340' side='right'caption='[[3v8d]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3v8d]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3v8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V8D FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GV:(3BETA,8ALPHA,9BETA)-3-HYDROXYCHOLEST-5-EN-7-ONE'>0GV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GV:(3BETA,8ALPHA,9BETA)-3-HYDROXYCHOLEST-5-EN-7-ONE'>0GV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP7A1, CYP7 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP7A1, CYP7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholesterol_7-alpha-monooxygenase Cholesterol 7-alpha-monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.17 1.14.13.17] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8d OCA], [https://pdbe.org/3v8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v8d RCSB], [https://www.ebi.ac.uk/pdbsum/3v8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v8d ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CP7A1_HUMAN CP7A1_HUMAN]] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.<ref>PMID:19965590</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Cholesterol 7-alpha-monooxygenase]] | [[Category: Cholesterol 7-alpha-monooxygenase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 08:39, 20 July 2022
Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
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