Stringent starvation protein

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== Structural highlights ==
== Structural highlights ==
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The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:18864445</ref>. The ppGpp molecule binds to the open face of the SspA-MglA heterodimer interacting with both molecules
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The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:28864445</ref>. The ppGpp molecule binds to the open face of the SspA-MglA heterodimer interacting with both molecules
== 3D structures of stringent starvation protein ==
== 3D structures of stringent starvation protein ==
[[Stringent starvation protein 3D structures]]
[[Stringent starvation protein 3D structures]]

Revision as of 08:51, 24 July 2022

SspA (pink, yellow) complex with MglA (green, grey), ppGpp, glycerol, PEG400 (PDB ID 5u51)

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References

  1. Wang F, Shi J, He D, Tong B, Zhang C, Wen A, Zhang Y, Feng Y, Lin W. Structural basis for transcription inhibition by E. coli SspA. Nucleic Acids Res. 2020 Sep 25;48(17):9931-9942. doi: 10.1093/nar/gkaa672. PMID:32785630 doi:http://dx.doi.org/10.1093/nar/gkaa672
  2. Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA. Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev. 2017 Aug 1;31(15):1549-1560. doi: 10.1101/gad.303701.117. Epub 2017, Sep 1. PMID:28864445 doi:http://dx.doi.org/10.1101/gad.303701.117

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Michal Harel, Alexander Berchansky

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