Stringent starvation protein

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== Relevance ==
== Relevance ==
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Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators.
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Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators<ref>PMID:31648246</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 09:08, 24 July 2022

SspA (pink, yellow) complex with MglA (green, grey), ppGpp, glycerol, PEG400 (PDB ID 5u51)

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References

  1. ↑ Hansen AM, Qiu Y, Yeh N, Blattner FR, Durfee T, Jin DJ. SspA is required for acid resistance in stationary phase by downregulation of H-NS in Escherichia coli. Mol Microbiol. 2005 May;56(3):719-34. doi: 10.1111/j.1365-2958.2005.04567.x. PMID:15819627 doi:http://dx.doi.org/10.1111/j.1365-2958.2005.04567.x
  2. ↑ Wang F, Shi J, He D, Tong B, Zhang C, Wen A, Zhang Y, Feng Y, Lin W. Structural basis for transcription inhibition by E. coli SspA. Nucleic Acids Res. 2020 Sep 25;48(17):9931-9942. doi: 10.1093/nar/gkaa672. PMID:32785630 doi:http://dx.doi.org/10.1093/nar/gkaa672
  3. ↑ Flynn JM, Levchenko I, Seidel M, Wickner SH, Sauer RT, Baker TA. Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10584-9. doi:, 10.1073/pnas.191375298. Epub 2001 Sep 4. PMID:11535833 doi:http://dx.doi.org/10.1073/pnas.191375298
  4. ↑ Ma Z, King K, Alqahtani M, Worden M, Muthuraman P, Cioffi CL, Bakshi CS, Malik M. Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis. PLoS One. 2019 Oct 24;14(10):e0224094. doi: 10.1371/journal.pone.0224094., eCollection 2019. PMID:31648246 doi:http://dx.doi.org/10.1371/journal.pone.0224094
  5. ↑ Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA. Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev. 2017 Aug 1;31(15):1549-1560. doi: 10.1101/gad.303701.117. Epub 2017, Sep 1. PMID:28864445 doi:http://dx.doi.org/10.1101/gad.303701.117

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Michal Harel, Alexander Berchansky

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