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3v9r

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'''Unreleased structure'''
 
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The entry 3v9r is ON HOLD until Paper Publication
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==Crystal structure of Saccharomyces cerevisiae MHF complex==
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<StructureSection load='3v9r' size='340' side='right'caption='[[3v9r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v9r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V9R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YOL086W-A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), YDL160C-A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v9r OCA], [https://pdbe.org/3v9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v9r RCSB], [https://www.ebi.ac.uk/pdbsum/3v9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v9r ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fanconi anemia (FA) is a chromosomal instability disorder associated with deficiencies in the Fanconi anemia complementation group (FANC) network. A complex consisting of FANCM-associated histone-fold proteins 1 and 2 (MHF1 and MHF2) has been shown to act cooperatively with FANCM in DNA damage repair in the FA pathway. Here we report the structure of Saccharomyces cerevisiae MHF complex in which MHF1 and MHF2 assume a typical histone fold, and the complex has a heterotetrameric architecture similar to that of the histones (H3-H4)(2) heterotetramer. Loop L2 of MHF1 is probably involved in DNA binding, and loop L3 and helices alpha2 and alpha3 of one MHF1 subunit interact with those of the other to form two heterotetramer interfaces. Further genetic data demonstrate that the heterotetramer assembly is essential for the function of the complex in DNA repair. These results provide, to the best of our knowledge, new mechanistic insights into the function of the MHF complex.
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Authors: Yang, H., Zhang, T., Zhong, C., Li, H., Zhou, J., Ding, J.
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Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer.,Yang H, Zhang T, Tao Y, Wu L, Li HT, Zhou JQ, Zhong C, Ding J Structure. 2012 Feb 8;20(2):364-70. PMID:22325783<ref>PMID:22325783</ref>
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Description: Crystal structure of Saccharomyces cerevesiae MHF complex
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3v9r" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: Ding, J]]
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[[Category: Li, H]]
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[[Category: Yang, H]]
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[[Category: Zhang, T]]
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[[Category: Zhong, C]]
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[[Category: Zhou, J]]
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[[Category: Dna binding protein]]
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[[Category: Dna repair]]
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[[Category: Fanconi anemia]]
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[[Category: Histone fold]]
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[[Category: Mhf1]]
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[[Category: Mhf2]]

Current revision

Crystal structure of Saccharomyces cerevisiae MHF complex

PDB ID 3v9r

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OCA

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