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3vmt
From Proteopedia
(Difference between revisions)
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==Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog== | ==Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog== | ||
| - | <StructureSection load='3vmt' size='340' side='right' caption='[[3vmt]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3vmt' size='340' side='right'caption='[[3vmt]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3vmt]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3vmt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VMT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHI:[(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3AS,4S,6AR)-2-OXIDANYLIDENE-1,3,3A,4,6,6A-HEXAHYDROTHIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYLAMINO]ETHOXY]ETHOXY]ETHYLAMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]AMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]OXY-3-ACETAMIDO-5-[(2S,3R,4R,5R,6R)-3-ACETAMIDO-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]OXY-6-(HYDROXYMETHYL)OXAN-2-YL]+[OXIDANYL(3,7,11,15,19,23,27,31,35,39,43-UNDECAMETHYLTETRATETRACONTA-2,6,10,14,18,22,26,30,34,38,42-UNDECAENOXY)PHOSPHORYL]+HYDROGEN+PHOSPHATE'>LHI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHI:[(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3AS,4S,6AR)-2-OXIDANYLIDENE-1,3,3A,4,6,6A-HEXAHYDROTHIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYLAMINO]ETHOXY]ETHOXY]ETHYLAMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]AMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]OXY-3-ACETAMIDO-5-[(2S,3R,4R,5R,6R)-3-ACETAMIDO-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]OXY-6-(HYDROXYMETHYL)OXAN-2-YL]+[OXIDANYL(3,7,11,15,19,23,27,31,35,39,43-UNDECAMETHYLTETRATETRACONTA-2,6,10,14,18,22,26,30,34,38,42-UNDECAENOXY)PHOSPHORYL]+HYDROGEN+PHOSPHATE'>LHI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vmq|3vmq]], [[3vmr|3vmr]], [[3vms|3vms]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vmq|3vmq]], [[3vmr|3vmr]], [[3vms|3vms]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGT ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vmt OCA], [https://pdbe.org/3vmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vmt RCSB], [https://www.ebi.ac.uk/pdbsum/3vmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vmt ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MGT_STAAM MGT_STAAM]] Involved in the biosynthesis of cell wall peptidoglycan. Responsible for the elongation of the glycan strands using lipid-linked disaccharide-pentapeptide as the substrate (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Glycosyltransferase|Glycosyltransferase]] | + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Staam]] | [[Category: Staam]] | ||
[[Category: Cheng, T J.R]] | [[Category: Cheng, T J.R]] | ||
Revision as of 18:53, 27 July 2022
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog
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