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1hu3
From Proteopedia
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[[Image:1hu3.gif|left|200px]] | [[Image:1hu3.gif|left|200px]] | ||
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'''MIDDLE DOMAIN OF HUMAN EIF4GII''' | '''MIDDLE DOMAIN OF HUMAN EIF4GII''' | ||
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[[Category: Pestova, T V.]] | [[Category: Pestova, T V.]] | ||
[[Category: Sonenberg, N.]] | [[Category: Sonenberg, N.]] | ||
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Revision as of 16:13, 2 May 2008
MIDDLE DOMAIN OF HUMAN EIF4GII
Overview
The X-ray structure of the phylogenetically conserved middle portion of human eukaryotic initiation factor (eIF) 4GII has been determined at 2.4 A resolution, revealing a crescent-shaped domain consisting of ten alpha helices arranged as five HEAT repeats. Together with the ATP-dependent RNA helicase eIF4A, this HEAT domain suffices for 48S ribosomal complex formation with a picornaviral RNA internal ribosome entry site (IRES). Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of this essential component of the translation initiation machinery that, respectively, bind eIF4A and a picornaviral IRES. The structural and biochemical results provide mechanistic insights into both cap-dependent and cap-independent translation initiation.
About this Structure
1HU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:11172724 Page seeded by OCA on Fri May 2 19:13:50 2008
