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3w0m

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==Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia, apo form==
==Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia, apo form==
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<StructureSection load='3w0m' size='340' side='right' caption='[[3w0m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3w0m' size='340' side='right'caption='[[3w0m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W0M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w0n|3w0n]], [[3w0o|3w0o]], [[3w0p|3w0p]], [[3w0q|3w0q]], [[3w0r|3w0r]], [[3w0s|3w0s]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w0n|3w0n]], [[3w0o|3w0o]], [[3w0p|3w0p]], [[3w0q|3w0q]], [[3w0r|3w0r]], [[3w0s|3w0s]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hph ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hygromycin_B_4-O-kinase Hygromycin B 4-O-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.163 2.7.1.163] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hygromycin_B_4-O-kinase Hygromycin B 4-O-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.163 2.7.1.163] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0m OCA], [http://pdbe.org/3w0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w0m RCSB], [http://www.ebi.ac.uk/pdbsum/3w0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0m ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0m OCA], [https://pdbe.org/3w0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0m RCSB], [https://www.ebi.ac.uk/pdbsum/3w0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KHYB_ECOLX KHYB_ECOLX]] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
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[[https://www.uniprot.org/uniprot/KHYB_ECOLX KHYB_ECOLX]] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Bacillus coli migula 1895]]
[[Category: Bacillus coli migula 1895]]
[[Category: Hygromycin B 4-O-kinase]]
[[Category: Hygromycin B 4-O-kinase]]
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[[Category: Large Structures]]
[[Category: Fukano, K]]
[[Category: Fukano, K]]
[[Category: Hoshino, T]]
[[Category: Hoshino, T]]

Revision as of 05:17, 3 August 2022

Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia, apo form

PDB ID 3w0m

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