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3w74
From Proteopedia
(Difference between revisions)
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==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139== | ==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139== | ||
| - | <StructureSection load='3w74' size='340' side='right' caption='[[3w74]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3w74' size='340' side='right'caption='[[3w74]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3w74]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3w74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W74 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=W74:2,6-DIOXO-5-{2-[4-(TRIFLUOROMETHOXY)PHENYL]ETHYL}-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W74</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=W74:2,6-DIOXO-5-{2-[4-(TRIFLUOROMETHOXY)PHENYL]ETHYL}-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W74</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w1a|3w1a]], [[3w1l|3w1l]], [[3w1m|3w1m]], [[3w1n|3w1n]], [[3w1p|3w1p]], [[3w1q|3w1q]], [[3w1r|3w1r]], [[3w1t|3w1t]], [[3w1u|3w1u]], [[3w1x|3w1x]], [[3w22|3w22]], [[3w23|3w23]], [[3w2j|3w2j]], [[3w2k|3w2k]], [[3w2l|3w2l]], [[3w2m|3w2m]], [[3w2n|3w2n]], [[3w2u|3w2u]], [[4jd4|4jd4]], [[4jdb|4jdb]], [[3w6y|3w6y]], [[3w70|3w70]], [[3w71|3w71]], [[3w72|3w72]], [[3w73|3w73]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w1a|3w1a]], [[3w1l|3w1l]], [[3w1m|3w1m]], [[3w1n|3w1n]], [[3w1p|3w1p]], [[3w1q|3w1q]], [[3w1r|3w1r]], [[3w1t|3w1t]], [[3w1u|3w1u]], [[3w1x|3w1x]], [[3w22|3w22]], [[3w23|3w23]], [[3w2j|3w2j]], [[3w2k|3w2k]], [[3w2l|3w2l]], [[3w2m|3w2m]], [[3w2n|3w2n]], [[3w2u|3w2u]], [[4jd4|4jd4]], [[4jdb|4jdb]], [[3w6y|3w6y]], [[3w70|3w70]], [[3w71|3w71]], [[3w72|3w72]], [[3w73|3w73]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w74 OCA], [https://pdbe.org/3w74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w74 RCSB], [https://www.ebi.ac.uk/pdbsum/3w74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w74 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. |
| + | |||
| + | ==See Also== | ||
| + | *[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Trycc]] | [[Category: Trycc]] | ||
[[Category: Aoki, T]] | [[Category: Aoki, T]] | ||
Revision as of 05:25, 3 August 2022
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139
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Categories: Large Structures | Trycc | Aoki, T | Balogun, E O | Harada, S | Hashimoto, S | Honma, T | Iida, M | Inaoka, D K | Inoue, M | Kita, K | Kuranaga, T | Lee, N | Matsuoka, S | Nara, T | Sakamoto, K | Shiba, T | Suzuki, S | Tabuchi, T | Tanaka, A | Cytosol | Dihydroorotate/orotate and fumarate/succinate binding | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Rossmann fold
