Stringent starvation protein
From Proteopedia
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| - | <StructureSection load='5u51' size='340' side='right' caption='SspA ( | + | <StructureSection load='5u51' size='340' side='right' caption='SspA (deep sky blue) complex with MglA (pink), ppGpp, glycerol, PEG400 (PDB ID [[5u51]])' scene='91/917934/Cv/2'> |
== Function == | == Function == | ||
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== Relevance == | == Relevance == | ||
| - | Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators. | + | Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators<ref>PMID:31648246</ref>. |
== Structural highlights == | == Structural highlights == | ||
| - | The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:28864445</ref>. | + | The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:28864445</ref>. The <scene name='91/917934/Cv/5'>ppGpp molecule binds to the open face of the SspA-MglA heterodimer interacting with both molecules</scene>. |
== 3D structures of stringent starvation protein == | == 3D structures of stringent starvation protein == | ||
[[Stringent starvation protein 3D structures]] | [[Stringent starvation protein 3D structures]] | ||
Current revision
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References
- ↑ Hansen AM, Qiu Y, Yeh N, Blattner FR, Durfee T, Jin DJ. SspA is required for acid resistance in stationary phase by downregulation of H-NS in Escherichia coli. Mol Microbiol. 2005 May;56(3):719-34. doi: 10.1111/j.1365-2958.2005.04567.x. PMID:15819627 doi:http://dx.doi.org/10.1111/j.1365-2958.2005.04567.x
- ↑ Wang F, Shi J, He D, Tong B, Zhang C, Wen A, Zhang Y, Feng Y, Lin W. Structural basis for transcription inhibition by E. coli SspA. Nucleic Acids Res. 2020 Sep 25;48(17):9931-9942. doi: 10.1093/nar/gkaa672. PMID:32785630 doi:http://dx.doi.org/10.1093/nar/gkaa672
- ↑ Flynn JM, Levchenko I, Seidel M, Wickner SH, Sauer RT, Baker TA. Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10584-9. doi:, 10.1073/pnas.191375298. Epub 2001 Sep 4. PMID:11535833 doi:http://dx.doi.org/10.1073/pnas.191375298
- ↑ Ma Z, King K, Alqahtani M, Worden M, Muthuraman P, Cioffi CL, Bakshi CS, Malik M. Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis. PLoS One. 2019 Oct 24;14(10):e0224094. doi: 10.1371/journal.pone.0224094., eCollection 2019. PMID:31648246 doi:http://dx.doi.org/10.1371/journal.pone.0224094
- ↑ Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA. Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev. 2017 Aug 1;31(15):1549-1560. doi: 10.1101/gad.303701.117. Epub 2017, Sep 1. PMID:28864445 doi:http://dx.doi.org/10.1101/gad.303701.117
