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2bn8

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Revision as of 05:23, 10 August 2022

Solution Structure and interactions of the E .coli Cell Division Activator Protein CedA

Structural highlights

2bn8 is a 1 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CEDA_ECOLI] Activates the cell division inhibited by chromosomal DNA over-replication.

Publication Abstract from PubMed

CedA is a protein that is postulated to be involved in the regulation of cell division in Escherichia coli and related organisms; however, little biological data about its possible mode of action are available. Here we present a three-dimensional structure of this protein as determined by NMR spectroscopy. The protein is made up of four antiparallel beta-strands, an alpha-helix, and a large unstructured stretch of residues at the N-terminus. It shows structural similarity to a family of DNA-binding proteins which interact with dsDNA via a three-stranded beta-sheet, suggesting that CedA may be a DNA-binding protein. The putative binding surface of CedA is predominantly positively charged with a number of basic residues surrounding a groove largely dominated by aromatic residues. NMR chemical shift perturbations and gel-shift experiments performed with CedA confirm that the protein binds dsDNA, and its interaction is mediated primarily via the beta-sheet.

Solution structure and interactions of the Escherichia coli cell division activator protein CedA.,Chen HA, Simpson P, Huyton T, Roper D, Matthews S Biochemistry. 2005 May 10;44(18):6738-44. PMID:15865419^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chen HA, Simpson P, Huyton T, Roper D, Matthews S. Solution structure and interactions of the Escherichia coli cell division activator protein CedA. Biochemistry. 2005 May 10;44(18):6738-44. PMID:15865419 doi:http://dx.doi.org/10.1021/bi0500269

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bn8"

@@ Line 3: / Line 3: @@
 <StructureSection load='2bn8' size='340' side='right'caption='[[2bn8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2bn8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2BN8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2bn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BN8 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bn8 OCA], [http://pdbe.org/2bn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bn8 RCSB], [http://www.ebi.ac.uk/pdbsum/2bn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bn8 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bn8 OCA], [https://pdbe.org/2bn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bn8 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CEDA_ECOLI CEDA_ECOLI]] Activates the cell division inhibited by chromosomal DNA over-replication.
+[[https://www.uniprot.org/uniprot/CEDA_ECOLI CEDA_ECOLI]] Activates the cell division inhibited by chromosomal DNA over-replication.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

2bn8

From Proteopedia

Revision as of 05:23, 10 August 2022

Solution Structure and interactions of the E .coli Cell Division Activator Protein CedA

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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