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3zgi

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{{STRUCTURE_3zgi| PDB=3zgi | SCENE= }}
 
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===Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP===
 
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==About this Structure==
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==Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP==
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[[3zgi]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGI OCA].
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<StructureSection load='3zgi' size='340' side='right'caption='[[3zgi]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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[[Category: Achour, A.]]
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== Structural highlights ==
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[[Category: Diamante, A.]]
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<table><tr><td colspan='2'>[[3zgi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGI FirstGlance]. <br>
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[[Category: Ebel, C.]]
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Henriques-Normark, B.]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Hentrich, K.]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zgh|3zgh]]</div></td></tr>
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[[Category: Kikhney, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgi OCA], [https://pdbe.org/3zgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgi RCSB], [https://www.ebi.ac.uk/pdbsum/3zgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgi ProSAT]</span></td></tr>
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[[Category: Loefling, J.]]
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</table>
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[[Category: Mikaelsson, C.]]
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<div style="background-color:#fffaf0;">
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[[Category: Normark, S.]]
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== Publication Abstract from PubMed ==
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[[Category: Schulte, T.]]
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Streptococcus pneumoniae is a major human pathogen, and a leading cause of disease and death worldwide. Pneumococcal invasive disease is triggered by initial asymptomatic colonization of the human upper respiratory tract. The pneumococcal serine-rich repeat protein (PsrP) is a lung-specific virulence factor whose functional binding region (BR) binds to keratin-10 (KRT10) and promotes pneumococcal biofilm formation through self-oligomerization. We present the crystal structure of the KRT10-binding domain of PsrP (BR187-385) determined to 2.0 A resolution. BR187-385 adopts a novel variant of the DEv-IgG fold, typical for microbial surface components recognizing adhesive matrix molecules adhesins, despite very low sequence identity. An extended beta-sheet on one side of the compressed, two-sided barrel presents a basic groove that possibly binds to the acidic helical rod domain of KRT10. Our study also demonstrates the importance of the other side of the barrel, formed by extensive well-ordered loops and stabilized by short beta-strands, for interaction with KRT10.
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[[Category: Svergun, D.]]
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The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.,Schulte T, Lofling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A Open Biol. 2014 Jan 15;4(1):130090. doi: 10.1098/rsob.130090. PMID:24430336<ref>PMID:24430336</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zgi" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Strpn]]
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[[Category: Achour, A]]
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[[Category: Diamante, A]]
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[[Category: Ebel, C]]
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[[Category: Henriques-Normark, B]]
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[[Category: Hentrich, K]]
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[[Category: Kikhney, A]]
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[[Category: Loefling, J]]
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[[Category: Mikaelsson, C]]
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[[Category: Normark, S]]
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[[Category: Schulte, T]]
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[[Category: Svergun, D]]
[[Category: Adhesin]]
[[Category: Adhesin]]
[[Category: Keratin-10]]
[[Category: Keratin-10]]
[[Category: Srrp]]
[[Category: Srrp]]
[[Category: Structural protein]]
[[Category: Structural protein]]

Current revision

Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP

PDB ID 3zgi

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