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1hxk

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[[Image:1hxk.gif|left|200px]]
[[Image:1hxk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hxk |SIZE=350|CAPTION= <scene name='initialview01'>1hxk</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1hxk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DMJ:1-DEOXYMANNOJIRIMYCIN'>DMJ</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1hxk| PDB=1hxk | SCENE= }}
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|RELATEDENTRY=[[1hty|1HTY]], [[1hww|1HWW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hxk OCA], [http://www.ebi.ac.uk/pdbsum/1hxk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hxk RCSB]</span>
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}}
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'''GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN'''
'''GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN'''
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[[Category: Rose, D R.]]
[[Category: Rose, D R.]]
[[Category: 2 c-terminal beta barrel]]
[[Category: 2 c-terminal beta barrel]]
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[[Category: n-terminal alpha-beta domain]]
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[[Category: N-terminal alpha-beta domain]]
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[[Category: three helix bundle]]
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[[Category: Three helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:20:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:11:42 2008''
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Revision as of 16:20, 2 May 2008

Image:1hxk.gif

Template:STRUCTURE 1hxk

GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN


Overview

Golgi alpha-mannosidase II, a key enzyme in N-glycan processing, is a target in the development of anti- cancer therapies. The crystal structure of Drosophila Golgi alpha-mannosidase II in the absence and presence of the anti-cancer agent swainsonine and the inhibitor deoxymannojirimycin reveals a novel protein fold with an active site zinc intricately involved both in the substrate specificity of the enzyme and directly in the catalytic mechanism. Identification of a putative GlcNAc binding pocket in the vicinity of the active site cavity provides a model for the binding of the GlcNAcMan(5)GlcNAc(2) substrate and the consecutive hydrolysis of the alpha1,6- and alpha1,3-linked mannose residues. The enzyme-inhibitor interactions observed provide insight into the catalytic mechanism, opening the door to the design of novel inhibitors of alpha-mannosidase II.

About this Structure

1HXK is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells., van den Elsen JM, Kuntz DA, Rose DR, EMBO J. 2001 Jun 15;20(12):3008-17. PMID:11406577 Page seeded by OCA on Fri May 2 19:20:00 2008

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