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7yxa
From Proteopedia
(Difference between revisions)
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==XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608== | ==XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608== | ||
| - | <StructureSection load='7yxa' size='340' side='right'caption='[[7yxa]]' scene=''> | + | <StructureSection load='7yxa' size='340' side='right'caption='[[7yxa]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7yxa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxa OCA], [https://pdbe.org/7yxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxa RCSB], [https://www.ebi.ac.uk/pdbsum/7yxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxa ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B2O:4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic+acid'>B2O</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxa OCA], [https://pdbe.org/7yxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxa RCSB], [https://www.ebi.ac.uk/pdbsum/7yxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxa ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/S1PR5_HUMAN S1PR5_HUMAN]] Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Borshchevskiy V]] | + | [[Category: Borshchevskiy, V]] |
| - | [[Category: Bourenkov G]] | + | [[Category: Bourenkov, G]] |
| - | [[Category: Bukhdruker S]] | + | [[Category: Bukhdruker, S]] |
| - | [[Category: Cherezov V]] | + | [[Category: Cherezov, V]] |
| - | [[Category: Cho Y]] | + | [[Category: Cho, Y]] |
| - | [[Category: Ergasheva M]] | + | [[Category: Ergasheva, M]] |
| - | [[Category: Gerasimov A]] | + | [[Category: Gerasimov, A]] |
| - | [[Category: Gordeliy V]] | + | [[Category: Gordeliy, V]] |
| - | [[Category: Gusach A]] | + | [[Category: Gusach, A]] |
| - | [[Category: Gushchin I]] | + | [[Category: Gushchin, I]] |
| - | [[Category: Hu H]] | + | [[Category: Hu, H]] |
| - | [[Category: Huyn | + | [[Category: Huyn, H J]] |
| - | [[Category: Khorn P]] | + | [[Category: Khorn, P]] |
| - | [[Category: Khusainov G]] | + | [[Category: Khusainov, G]] |
| - | [[Category: Kovalev K]] | + | [[Category: Kovalev, K]] |
| - | [[Category: Kovaleva M]] | + | [[Category: Kovaleva, M]] |
| - | [[Category: Liu W]] | + | [[Category: Liu, W]] |
| - | [[Category: Luginina A]] | + | [[Category: Luginina, A]] |
| - | [[Category: Lyapina E]] | + | [[Category: Lyapina, E]] |
| - | [[Category: Marin E]] | + | [[Category: Marin, E]] |
| - | [[Category: Mishin A]] | + | [[Category: Mishin, A]] |
| - | [[Category: Okhrimenko I]] | + | [[Category: Okhrimenko, I]] |
| - | [[Category: Orekhov P]] | + | [[Category: Orekhov, P]] |
| - | [[Category: Park G]] | + | [[Category: Park, G]] |
| - | [[Category: Park J]] | + | [[Category: Park, J]] |
| - | [[Category: Park S]] | + | [[Category: Park, S]] |
| - | [[Category: Popov P]] | + | [[Category: Popov, P]] |
| - | [[Category: Rogachev A]] | + | [[Category: Rogachev, A]] |
| - | [[Category: Shevtsov M]] | + | [[Category: Shevtsov, M]] |
| - | [[Category: Vakhrameev D]] | + | [[Category: Vakhrameev, D]] |
| - | [[Category: Weierstall U]] | + | [[Category: Weierstall, U]] |
| + | [[Category: G-protein coupled receptor]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: S1p5]] | ||
| + | [[Category: Serial femtosecond crystallography]] | ||
| + | [[Category: Sfx]] | ||
| + | [[Category: Sphingosine-1-phosphate]] | ||
| + | [[Category: Sphingosine-1-phosphate receptor]] | ||
| + | [[Category: X-ray free electron laser]] | ||
| + | [[Category: Xfel]] | ||
Revision as of 06:48, 18 August 2022
XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608
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Categories: Large Structures | Borshchevskiy, V | Bourenkov, G | Bukhdruker, S | Cherezov, V | Cho, Y | Ergasheva, M | Gerasimov, A | Gordeliy, V | Gusach, A | Gushchin, I | Hu, H | Huyn, H J | Khorn, P | Khusainov, G | Kovalev, K | Kovaleva, M | Liu, W | Luginina, A | Lyapina, E | Marin, E | Mishin, A | Okhrimenko, I | Orekhov, P | Park, G | Park, J | Park, S | Popov, P | Rogachev, A | Shevtsov, M | Vakhrameev, D | Weierstall, U | G-protein coupled receptor | Gpcr | Membrane protein | S1p5 | Serial femtosecond crystallography | Sfx | Sphingosine-1-phosphate | Sphingosine-1-phosphate receptor | X-ray free electron laser | Xfel
